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DNAJC19 Antibody

  • 货号：
    CSB-PA853400ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: DNAJC19 antibody at 0.96µg/ml
      Lane 1: Mouse kidney tissue
      Lane 2: A549 whole cell lysate
      Lane 3: HL60 whole cell lysate
      Lane 4: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 13, 11 kDa
      Observed band size: 13 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA853400ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA853400ESR1HU at dilution of 1:100
    • Immunoprecipitating DNAJC19 in Hela whole cell lysate
      Lane 1: Rabbit control IgG instead of CSB-PA853400ESR1HU in Hela whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA853400ESR1HU (8µg) + Hela whole cell lysate (500µg)
      Lane 3: Hela whole cell lysate (10µg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DNAJC19 Polyclonal antibody
  • Uniprot No.：
    Q96DA6
  • 基因名：
  • 别名：
    DnaJ (Hsp40) homolog; subfamily C; member 19 antibody; DnaJ homolog subfamily C member 19 antibody; DNAJC19 antibody; homolog of yeast TIM14 antibody; Mitochondrial import inner membrane translocase subunit TIM14 antibody; PAM18 antibody; TIM 14 antibody; TIM14 antibody; TIM14_HUMAN antibody; TIMM 14 antibody; TIMM14 antibody; translocase of the inner mitochondrial membrane 14 antibody; Translocase of the inner mitochondrial membrane 14; yeast homolog of antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Mitochondrial import inner membrane translocase subunit TIM14 protein (1-116AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling. May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity.
  • 基因功能参考文献：
    1. Both DnaJC15 and DnaJC19 formed two distinct subcomplexes with Magmas at the import channel. PMID: 27330077
    2. The loss of DNAJC19/PHB complexes affects cardiolipin acylation and leads to the accumulation of cardiolipin species with altered acyl chains. PMID: 24856930
    3. A report of a new mutation in the human DNAJC19 gene that causes early onset dilated cardiomyopathy syndrome in two brothers of Finnish origin. PMID: 22797137
    4. The association of dilated cardiomyopathy with ataxia (DCMA) syndrome with a segment of 3q26.33 and the identification of a splice mutation in a novel gene DNAJC19 in DCMA patients. PMID: 16055927
    5. Dilated cardiomyopathy caused by homozygous mutations in a novel gene, DNAJC19, presumed to play a role in importation of mitochondrial proteins. PMID: 17244376

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  • 相关疾病：
    3-methylglutaconic aciduria 5 (MGA5)
  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
  • 蛋白家族：
    TIM14 family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 30528

    OMIM: 608977

    KEGG: hsa:131118

    STRING: 9606.ENSP00000372005

    UniGene: Hs.230601