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DLGAP1 Antibody

  • 货号：
    CSB-PA004048
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using SAPAP1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O14490
  • 基因名：
  • 别名：
    4933422O14Rik antibody; 9630002F18 antibody; AI845682 antibody; AI848168 antibody; BB075781 antibody; D17Bwg0511e antibody; DAP 1 ALPHA antibody; DAP 1 antibody; DAP 1 BETA antibody; DAP-1 antibody; DAP-1-ALPHA antibody; DAP-1-BETA antibody; DAP1 antibody; Discs large (Drosophila) homolog associated protein 1 antibody; Discs large homolog associated protein 1 antibody; Disks large associated protein 1 antibody; Disks large associated protein 1; alpha isoform; included antibody; Disks large associated protein 1; beta isoform; included antibody; Disks large-associated protein 1 antibody; DLGAP 1 antibody; Dlgap1 antibody; DLGP1_HUMAN antibody; GKAP antibody; GKAP/SAPAP antibody; GKPA/SAPAP antibody; Guanylate kinase associated protein antibody; Guanylate kinase-associated protein antibody; hGKAP antibody; KIAA4162 antibody; MGC88156 antibody; mKIAA4162 antibody; PSD 95/SAP90 binding protein 1 antibody; PSD-95/SAP90-binding protein 1 antibody; SAP90/PSD 95 associated protein 1 antibody; SAP90/PSD-95-associated protein 1 antibody; SAPAP 1 antibody; SAPAP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human SAPAP1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Part of the postsynaptic scaffold in neuronal cells.
  • 基因功能参考文献：
    1. This study revealed a significant variant (rs12455524) within the gene DLGAP1 for Recurrent major depression. PMID: 26485182
    2. These results strongly suggested involvement of the DLGAP1 gene product in the development of HIV-related lipoatrophy in Thai HIV patients. PMID: 25950743
    3. This study showed that DLGAP1 association with obsessive-compulsive disorder. PMID: 24821223
    4. Dimerization of DLC2 was required for its interaction with GKAP, which, in turn, potentiated GKAP self-association. PMID: 24938595
    5. Results show that the expression and distribution of NMDA receptors subunits GluN1, GluN2A and GluN2B - together with that of postsynaptic protein PSD-95 - are modified in Alzheimer's disease compared to normal aging PMID: 24156266
    6. dlgap1 showed the highest association, of snps examined, with ocd. PMID: 22889921
    7. Study identified six genetic variants, (rs145691437, rs3786431, rs201567254, rs3745051 and rs11662259) and one rare missense mutation (c.1922A>G). SNP- and haplotype-based analyses showed no association of these SNPs with schizophrenia. PMID: 22940546
    8. The GKAP controls the forces operating on microtubules and play a fundamental role in centrosome positioning and cell polarity. PMID: 21041448

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
  • 蛋白家族：
    SAPAP family
  • 组织特异性：
    Expressed in brain.
  • 数据库链接：

    HGNC: 2905

    OMIM: 605445

    KEGG: hsa:9229

    STRING: 9606.ENSP00000316377

    UniGene: Hs.594640