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DLGAP1 Antibody

  • 货号：
    CSB-PA778288
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HepG2 cells, using DLGP1 antibody.
    • Immunofluorescence analysis of HeLa cells, using DLGP1 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DLGAP1 Polyclonal antibody
  • Uniprot No.：
    O14490
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human DLGP1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Part of the postsynaptic scaffold in neuronal cells.
  • 基因功能参考文献：
    1. This study revealed a significant variant (rs12455524) within the gene DLGAP1 for Recurrent major depression. PMID: 26485182
    2. These results strongly suggested involvement of the DLGAP1 gene product in the development of HIV-related lipoatrophy in Thai HIV patients. PMID: 25950743
    3. This study showed that DLGAP1 association with obsessive-compulsive disorder. PMID: 24821223
    4. Dimerization of DLC2 was required for its interaction with GKAP, which, in turn, potentiated GKAP self-association. PMID: 24938595
    5. Results show that the expression and distribution of NMDA receptors subunits GluN1, GluN2A and GluN2B - together with that of postsynaptic protein PSD-95 - are modified in Alzheimer's disease compared to normal aging PMID: 24156266
    6. dlgap1 showed the highest association, of snps examined, with ocd. PMID: 22889921
    7. Study identified six genetic variants, (rs145691437, rs3786431, rs201567254, rs3745051 and rs11662259) and one rare missense mutation (c.1922A>G). SNP- and haplotype-based analyses showed no association of these SNPs with schizophrenia. PMID: 22940546
    8. The GKAP controls the forces operating on microtubules and play a fundamental role in centrosome positioning and cell polarity. PMID: 21041448

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
  • 蛋白家族：
    SAPAP family
  • 组织特异性：
    Expressed in brain.
  • 数据库链接：

    HGNC: 2905

    OMIM: 605445

    KEGG: hsa:9229

    STRING: 9606.ENSP00000316377

    UniGene: Hs.594640