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DACH1 Antibody

  • 货号：
    CSB-PA999451
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA999451(DACH1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA999451(DACH1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9UI36
  • 基因名：
    DACH1
  • 别名：
    DACH antibody; Dach1 antibody; DACH1_HUMAN antibody; Dachshund family transcription factor 1 antibody; dachshund homolog 1 (Drosophila) antibody; Dachshund homolog 1 antibody; Dachsund homolog 1 antibody; FLJ10138 antibody; OTTHUMP00000018494 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human DACH1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:100-1:300
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.
  • 基因功能参考文献：
    1. DACH1 expression is decreased in glomerulopathy imply a potential role for DACH1 in the this development of human chornic glomerulopathy. PMID: 27888806
    2. Knockdown of DACH1 expression can remarkably enhance the cell apoptosis, restrain the proliferation, migration and invasion of Capan-1 cells. PMID: 27609579
    3. DACH1 expression regulates the pancreatic cancer cell apoptosis. PMID: 27278537
    4. Low DACH1 expression is associated with invasion of lung adenocarcinoma. PMID: 26810067
    5. This study concludes that MiR-217 is the upstream regulator of PGC-1alpha in breast cancer regulation in vitro, possibly independent of DACH1 signaling pathway. PMID: 27916422
    6. Kaplan-Mier analysis of human NSCLC samples demonstrated that high DACH1 mRNA levels predicted favorable prognosis for relapse-free and overall survival. In agreement, high CXCL5 expression predicted a worse prognosis for survival. PMID: 25788272
    7. DACH1 expression was reduced in hepatocellular carcinoma even at early stage and associated with tumor progression. Overexpression inhibited HCC cell growth and migration by inactivating the Wnt pathway via GSK3beta phosphorylation to suppress beta-catenin. PMID: 25940701
    8. In breast cancer, some GATA3 effects shift from tumor suppressing to tumor promoting during tumorigenesis, with deregulation of three genes, BCL2, DACH1, THSD4, representing major GATA3-controlled processes in cancer progression. PMID: 25410484
    9. Results indicated that DACH1 was a novel molecular marker of RCC and it attributed to the malignant behavior of renal cancer cells. PMID: 25322986
    10. Data indicate that dachshund family transcription factor 1 (DACH1) suppresses gastric cancer cell proliferation, invasion and metastasis by inhibiting transforming growth factor beta (TGF-beta) signalling pathways both in vitro and in vivo. PMID: 24912879
    11. results suggest that DACH1 loss of function results in increased cell growth, motility and invasiveness through TGF-beta-mediated EMT, and DACH1 loss of function has important therapeutic implications for targeted therapies of CRC PMID: 25778865
    12. DACH1 is a determinant of benign and malignant prostate epithelium cellular growth, migration, and cytokine abundance in vivo. PMID: 25769723
    13. Further evaluation of the methylation of DACH1, DKK1, and WIF1 in a clinical patient group confirmed the frequent methylation of WIF1 and intermediate or low frequency of methylation of DACH1 or DKK1, respectively. PMID: 25487617
    14. DACH1 inhibits aldosterone secretion in human adrenals, and transforming growth factor-beta signaling pathway is activated in DACH1 overexpressed cells and may mediate inhibition of aldosterone secretion in human adrenals. PMID: 25776071
    15. Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese PMID: 24465431
    16. Nuclear DACH1 expression appears to be a Luminal A biomarker predictive of good prognosis, but is not independent of clinical stage, tumour size, NPI status or systemic therapy. PMID: 24392136
    17. DACH1 is frequently methylated in human colorectal cancers (CRC) and methylation of DACH1 may serve as detective and prognostic marker in CRC. PMID: 24149323
    18. Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation. PMID: 24335958
    19. DACH1 binds p53 to inhibit NSCLC cellular growth. PMID: 23492369
    20. DACH1 gene promoter methylation could lead to a decrease or absence of DACH1 expression in endometrial carcinoma. PMID: 22781112
    21. the inability of C/EBPalpha and GATA-1 to down-regulate DACH1 expression induced by MLL-AF9 during myeloid differentiation may contribute to t(9;11) leukemogenesis. PMID: 22902925
    22. DACH1 is highly expressed in metastatic ovarian cancer compared with that of normal, benign, and borderline ovarian tissues and could play an important role in cancer growth. PMID: 22367319
    23. The knockdown of DACH1 blocked the cell cycle progression of HL-60 promyeloblastic cells through the decrease of cyclin D1, D3, F, and Cdk 1, 4, and 6 and increase in p21(Cip1), which in turn decreased the phosphorylation of the Rb protein. PMID: 22405764
    24. in cells growing in IGF-1 (and unresponsive to EGF), DACH1 is devoid of tumor suppressor activity. PMID: 21558809
    25. DACH1 is a distinctive tumor suppressor, which not only suppresses growth of tumor cells but also regulates bFGF-mediated tumor-initiating activity of glioma cells PMID: 21750150
    26. DACH1 represses gene transcription through direct DNA binding to the promoter region of target genes by recruiting the transcriptional co-regulator, TCERG1. PMID: 20956529
    27. Forkhead signaling is attenuated by the retinal determination factor DACH1 PMID: 20351289
    28. The altered expression of human DACH1 has been associated with tumor progression and metastasis. DACH1 inhibits breast cancer cellular proliferation via cyclin D1. PMID: 19502783
    29. Findings identify a role of EYA4 and possibly interacting SIX and DACH proteins in MPNSTs and suggest the EYA4 pathway as a rational therapeutic target. PMID: 19901965
    30. forms an alpha/beta structure containing a DNA binding motif similar PMID: 12057194
    31. DACH1 bound to endogenous NCoR and Smad4 in cultured cells; Smad4 was required for DACH1 repression of TGF-beta induction of Smad signaling PMID: 14525983
    32. identifed DACH enhancers in gene deserts PMID: 14563999
    33. The dachshund is required in mushroom body neurons for proper axon guidance and branching in Drosophila melanogaster. PMID: 15818552
    34. DACH1 repressed cyclin D1 through a novel mechanism via a c-Jun DNA-binding partner, requiring the DACH1 alpha-helical DS domain which recruits corepressors to the local chromatin. PMID: 16980615
    35. DACH1 plays an important role in negative regulation of RANKL gene expression in marrow stromal/preosteoblast cells in the bone microenvironment. PMID: 17891780
    36. These data identify a pathway by which an endogenous cell-fate determination factor blocks oncogene-dependent tumor metastasis via a key heterotypic mediator. PMID: 18467491
    37. DACH1 is hypermethylated in renal cell carcinoma. PMID: 18639284
    38. a statistical significance level for DACH1 in gastric cancer PMID: 18957060
    39. DACH1 inhibited ligand-dependent activity of AR mutations identified in patients with androgen-insensitive prostate cancer. The DS domain was sufficient for repression of the AR wild-type but failed to repress an AR acetylation site point mutant. PMID: 19351840
    40. Data show that DACH1 expression, which is lost in poor prognosis human breast cancer, functions as an endogenous inhibitor of ERalpha function. PMID: 19605405

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    DACH/dachshund family
  • 组织特异性：
    Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen.
  • 数据库链接：

    HGNC: 2663

    OMIM: 603803

    KEGG: hsa:1602

    UniGene: Hs.129452