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  4. Cleaved-KLK11 (I54) Antibody

Cleaved-KLK11 (I54) Antibody

  • 货号：
    CSB-PA000045
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HeLa cells using Cleaved-KLK11 (I54) Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9UBX7
  • 基因名：
    KLK11
  • 别名：
    Hippostasin antibody; hK11 antibody; Kallikrein 11 antibody; Kallikrein 11 isoform 1 preproprotein antibody; Kallikrein 11 isoform 2 precursor antibody; Kallikrein 11 precursor antibody; Kallikrein related peptidase 11 antibody; Kallikrein-11 inactive chain 2 antibody; KLK 11 antibody; Klk11 antibody; KLK11_HUMAN antibody; MGC33060 antibody; Protease serine 20 trypsin like antibody; Protease serine trypsin like antibody; PRSS20 antibody; Serine protease 20 antibody; TLSP antibody; Trypsin like protease antibody; Trypsin-like protease antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human KLK11.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
  • 基因功能参考文献：
    1. Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases PMID: 29095848
    2. Variations in KLK15, but not KLK11 expression were significantly associated with prognosis in gastric cancer PMID: 26224476
    3. KLK11 mRNA expression could be considered as a new molecular prognostic biomarker in colorectal adenocarcinoma PMID: 25123036
    4. hK11 expression in gastric cancer appears to be associated with a better prognosis. hK11 may be a prognostic biomarker of gastric cancer. PMID: 24169449
    5. The aim of this study was to monitor serum levels of two microRNAs (miR-21 and miR-141) and three kallikreins (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy. PMID: 24288670
    6. Our data showed that UVB-induced TSLP might increase secretion of the T-helper type 2-attracting chemokine (c-c motif) ligand 17 by human dendritic cells. PMID: 23639975
    7. HOXB8 and KLK11 may be classified as valuable biomarkers, as they can predict the effects of FOLFOX4 chemotherapy in primary advanced colorectal cancer patients PMID: 23647300
    8. Human airway trypsin-like protease can stimulate mucin5AC hypersecretion through a PAR2-mediated signaling pathway in 16HBE cells. PMID: 23602830
    9. Patients harboring KLK11-positive tumors had a significantly decreased risk of death. PMID: 22429520
    10. Low KLK11 protein expression is associated with gastric cancer. PMID: 21618246
    11. For the first time, we report lower expression of KLK11 in CaP compared to BPH and slight upregulation of KLK11 in advanced tumors compared to localized ones PMID: 21520985
    12. the up-regulation of TMPRSS2 and the down-regulation of KLK11 in advanced and more aggressive tumors may open the feasibility of being used as biomarkers distinguishing the tumor aggressiveness as well as novel prognostic indicators for prostate cancer. PMID: 19242826
    13. hK11 may be another prognostic biomarker of low rectal carcinoma. Strong positive hK11 staining associated with various clinicopathologic features. Patients with weak hK11 positive expression showed better survival rates. PMID: 19184568
    14. Data show that it was unable to distinguish men with and without prostate cancer using multiple kallikreins as urinary biomarkers. PMID: 19560453
    15. may be useful marker for distinguishing prostate cancer and benign prostatic hypertrophy PMID: 11550212
    16. Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma. PMID: 11782391
    17. Hippostasin isoform 3 may play a role in the prostate, including reproductive and/or tumorigenic functions. PMID: 12539228
    18. There is a significant association between lower expression of prostate-type KLK11 and higher tumor stage, Gleason score, and tumor grade. PMID: 12736044
    19. hK11 is a novel, independent marker of favorable prognosis in patients with ovarian cancer PMID: 12845660
    20. KLK11 expression may play an important role in ovarian cancer development PMID: 15102682
    21. Kallikrein 11 is an independent marker of favorable prognosis in ovarian cancer patients. PMID: 15329323
    22. KLK11 was found to be highly expressed in 43/66 (65%) of prostate cancer samples PMID: 15893744
    23. results suggest a co-regulation of KLK10 and KLK11 expression in lung and a lack of KLK10 suppressor role in non-small-cell lung cancer PMID: 16800740
    24. The gene promoter regions of kallikrein and the corresponding transcriptional initiation sites were studied. PMID: 16911518
    25. The hormone-specific upregulation of PSA, KLK10 and KLK11 in the breast cancer cell line T47D is dependent on major intracellular signaling pathways. PMID: 18515984
    26. Treatment of PC3 prostate cancer cells with mitoxantrone, etoposide, doxorubicin and carboplatin induces distinct alterations in the expression of kallikreins 5 and 11. PMID: 19190824
    27. synergistic effects between estrogens and androgens on estrogen-sensitive genes may have implications on the role of the kallikreins 10, 11, and 14 in associated risk of breast cancer and progression. PMID: 19383315

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  • 亚细胞定位：
    [Isoform 1]: Secreted.; [Isoform 2]: Golgi apparatus.
  • 蛋白家族：
    Peptidase S1 family, Kallikrein subfamily
  • 组织特异性：
    Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
  • 数据库链接：

    HGNC: 6359

    OMIM: 604434

    KEGG: hsa:11012

    STRING: 9606.ENSP00000473047

    UniGene: Hs.57771