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  4. Recombinant Human Kallikrein-11 (KLK11)

Recombinant Human Kallikrein-11 (KLK11)

  • 中文名称：
    人KLK11重组蛋白
  • 货号：
    CSB-YP880069HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人KLK11重组蛋白
  • 货号：
    CSB-EP880069HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人KLK11重组蛋白
  • 货号：
    CSB-EP880069HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人KLK11重组蛋白
  • 货号：
    CSB-BP880069HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人KLK11重组蛋白
  • 货号：
    CSB-MP880069HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KLK11
  • Uniprot No.：
  • 别名：
    Hippostasin; hK11; Kallikrein 11; Kallikrein 11 isoform 1 preproprotein; Kallikrein 11 isoform 2 precursor; Kallikrein 11 precursor ; Kallikrein related peptidase 11; Kallikrein-11 inactive chain 2; KLK 11; Klk11; KLK11_HUMAN; MGC33060; Protease serine 20 trypsin like; Protease serine trypsin like; PRSS20; Serine protease 20; TLSP; Trypsin like protease; Trypsin-like protease
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    54-282
  • 氨基酸序列
    IIKGFEC KPHSQPWQAA LFEKTRLLCG ATLIAPRWLL TAAHCLKPRY IVHLGQHNLQ KEEGCEQTRT ATESFPHPGF NNSLPNKDHR NDIMLVKMAS PVSITWAVRP LTLSSRCVTA GTSCLISGWG STSSPQLRLP HTLRCANITI IEHQKCENAY PGNITDTMVC ASVQEGGKDS CQGDSGGPLV CNQSLQGIIS WGQDPCAITR KPGVYTKVCK YVDWIQETMK NN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
  • 基因功能参考文献：
    1. Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases PMID: 29095848
    2. Variations in KLK15, but not KLK11 expression were significantly associated with prognosis in gastric cancer PMID: 26224476
    3. KLK11 mRNA expression could be considered as a new molecular prognostic biomarker in colorectal adenocarcinoma PMID: 25123036
    4. hK11 expression in gastric cancer appears to be associated with a better prognosis. hK11 may be a prognostic biomarker of gastric cancer. PMID: 24169449
    5. The aim of this study was to monitor serum levels of two microRNAs (miR-21 and miR-141) and three kallikreins (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy. PMID: 24288670
    6. Our data showed that UVB-induced TSLP might increase secretion of the T-helper type 2-attracting chemokine (c-c motif) ligand 17 by human dendritic cells. PMID: 23639975
    7. HOXB8 and KLK11 may be classified as valuable biomarkers, as they can predict the effects of FOLFOX4 chemotherapy in primary advanced colorectal cancer patients PMID: 23647300
    8. Human airway trypsin-like protease can stimulate mucin5AC hypersecretion through a PAR2-mediated signaling pathway in 16HBE cells. PMID: 23602830
    9. Patients harboring KLK11-positive tumors had a significantly decreased risk of death. PMID: 22429520
    10. Low KLK11 protein expression is associated with gastric cancer. PMID: 21618246
    11. For the first time, we report lower expression of KLK11 in CaP compared to BPH and slight upregulation of KLK11 in advanced tumors compared to localized ones PMID: 21520985
    12. the up-regulation of TMPRSS2 and the down-regulation of KLK11 in advanced and more aggressive tumors may open the feasibility of being used as biomarkers distinguishing the tumor aggressiveness as well as novel prognostic indicators for prostate cancer. PMID: 19242826
    13. hK11 may be another prognostic biomarker of low rectal carcinoma. Strong positive hK11 staining associated with various clinicopathologic features. Patients with weak hK11 positive expression showed better survival rates. PMID: 19184568
    14. Data show that it was unable to distinguish men with and without prostate cancer using multiple kallikreins as urinary biomarkers. PMID: 19560453
    15. may be useful marker for distinguishing prostate cancer and benign prostatic hypertrophy PMID: 11550212
    16. Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma. PMID: 11782391
    17. Hippostasin isoform 3 may play a role in the prostate, including reproductive and/or tumorigenic functions. PMID: 12539228
    18. There is a significant association between lower expression of prostate-type KLK11 and higher tumor stage, Gleason score, and tumor grade. PMID: 12736044
    19. hK11 is a novel, independent marker of favorable prognosis in patients with ovarian cancer PMID: 12845660
    20. KLK11 expression may play an important role in ovarian cancer development PMID: 15102682
    21. Kallikrein 11 is an independent marker of favorable prognosis in ovarian cancer patients. PMID: 15329323
    22. KLK11 was found to be highly expressed in 43/66 (65%) of prostate cancer samples PMID: 15893744
    23. results suggest a co-regulation of KLK10 and KLK11 expression in lung and a lack of KLK10 suppressor role in non-small-cell lung cancer PMID: 16800740
    24. The gene promoter regions of kallikrein and the corresponding transcriptional initiation sites were studied. PMID: 16911518
    25. The hormone-specific upregulation of PSA, KLK10 and KLK11 in the breast cancer cell line T47D is dependent on major intracellular signaling pathways. PMID: 18515984
    26. Treatment of PC3 prostate cancer cells with mitoxantrone, etoposide, doxorubicin and carboplatin induces distinct alterations in the expression of kallikreins 5 and 11. PMID: 19190824
    27. synergistic effects between estrogens and androgens on estrogen-sensitive genes may have implications on the role of the kallikreins 10, 11, and 14 in associated risk of breast cancer and progression. PMID: 19383315

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  • 亚细胞定位：
    [Isoform 1]: Secreted.; [Isoform 2]: Golgi apparatus.
  • 蛋白家族：
    Peptidase S1 family, Kallikrein subfamily
  • 组织特异性：
    Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
  • 数据库链接：

    HGNC: 6359

    OMIM: 604434

    KEGG: hsa:11012

    STRING: 9606.ENSP00000473047

    UniGene: Hs.57771