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  4. Cleaved-CTSZ (L62) Antibody

Cleaved-CTSZ (L62) Antibody

  • 货号：
    CSB-PA000038
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COS7 cells using Cleaved-Cathepsin Z (L62) Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9UBR2
  • 基因名：
  • 别名：
    Carboxypeptidase LB antibody; Cathepsin B2 antibody; Cathepsin IV antibody; Cathepsin P antibody; Cathepsin X antibody; Cathepsin X precursor antibody; Cathepsin Y antibody; Cathepsin Z antibody; Cathepsin Z precursor antibody; Cathepsin Z1 antibody; CathepsinP antibody; CathepsinX antibody; CathepsinZ antibody; CATZ_HUMAN antibody; CTSX antibody; CTSZ antibody; Cysteine type carboxypeptidase antibody; FLJ17088 antibody; Lysosomal carboxypeptidase B antibody; Preprocathepsin P antibody; PreprocathepsinP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Monkey
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Cathepsin Z.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides.
  • 基因功能参考文献：
    1. Down-regulation of RPLP0 resulted in G1 arrest of gastric cancer cells, whereas knockdown of Cathepsin X led to G1 arrest and apoptosis PMID: 25433997
    2. Cathepsin X (CTSX) is involved in early tumorigenesis and in the stabilization of tumor cell formation in colorectal cancer. PMID: 25442015
    3. The significant association of cathepsin X with survival in a group of patients who received no chemotherapy and the absence of this association in the group who received chemotherapy, suggest the possible predictive value for response to chemotherapy. PMID: 24725597
    4. Suggest CTSZ rs34069356 polymorphism is not associated with pulmonary tuberculosis in a sample Iranian population. PMID: 23827504
    5. We show that sequential cleavage of C-terminal amino acids from the beta(2) cytoplasmic tail of LFA-1, by CatX, enhances binding of the adaptor protein talin to LFA-1 and triggers formation of the latter's high-affinity form PMID: 21454358
    6. cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma PMID: 21966391
    7. cathepsin X deficiency leads to accelerated cellular senescence and consequently to diminished cellular proliferation and migration/invasion implying a potential role of cathepsin X in bypassing cellular senescence. PMID: 21616554
    8. Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility. PMID: 21368909
    9. associated with tuberculosis in a Ugandan household contact study PMID: 21354459
    10. Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin. PMID: 21310951
    11. These results show that cathepsin P, in contrast to other mammalian cathepsins, has a restricted catalytic specificity. PMID: 15680921
    12. the extracellular function of cathepsin X may include binding to integrins thereby modulating the attachment of migrating cells to ECM components [Cathepsin X] PMID: 17065156
    13. unlikely that CTSZ gene plays a major role in tuberculosis susceptibility in African populations PMID: 18420963

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  • 亚细胞定位：
    Lysosome.
  • 蛋白家族：
    Peptidase C1 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 2547

    OMIM: 603169

    KEGG: hsa:1522

    STRING: 9606.ENSP00000217131

    UniGene: Hs.252549