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  4. Recombinant Human Cathepsin Z (CTSZ)

Recombinant Human Cathepsin Z (CTSZ)

  • 中文名称：
    Recombinant Human Cathepsin Z(CTSZ),Yeast
  • 货号：
    CSB-YP006206HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Cathepsin Z(CTSZ),Yeast
  • 货号：
    CSB-EP006206HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Cathepsin Z(CTSZ),Yeast
  • 货号：
    CSB-EP006206HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Cathepsin Z(CTSZ),Yeast
  • 货号：
    CSB-BP006206HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Cathepsin Z(CTSZ),Yeast
  • 货号：
    CSB-MP006206HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Carboxypeptidase LB; Cathepsin B2; Cathepsin IV; Cathepsin P; Cathepsin X; Cathepsin X precursor; Cathepsin Y; Cathepsin Z; Cathepsin Z precursor; Cathepsin Z1; CathepsinP; CathepsinX; CathepsinZ; CATZ_HUMAN; CTSX; CTSZ; Cysteine type carboxypeptidase; FLJ17088; Lysosomal carboxypeptidase B; Preprocathepsin P; PreprocathepsinP
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    62-303
  • 氨基酸序列
    LPKSWDWRN VDGVNYASIT RNQHIPQYCG SCWAHASTSA MADRINIKRK GAWPSTLLSV QNVIDCGNAG SCEGGNDLSV WDYAHQHGIP DETCNNYQAK DQECDKFNQC GTCNEFKECH AIRNYTLWRV GDYGSLSGRE KMMAEIYANG PISCGIMATE RLANYTGGIY AEYQDTTYIN HVVSVAGWGI SDGTEYWIVR NSWGEPWGER GWLRIVTSTY KDGKGARYNL AIEEHCTFGD PIV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides.
  • 基因功能参考文献：
    1. Down-regulation of RPLP0 resulted in G1 arrest of gastric cancer cells, whereas knockdown of Cathepsin X led to G1 arrest and apoptosis PMID: 25433997
    2. Cathepsin X (CTSX) is involved in early tumorigenesis and in the stabilization of tumor cell formation in colorectal cancer. PMID: 25442015
    3. The significant association of cathepsin X with survival in a group of patients who received no chemotherapy and the absence of this association in the group who received chemotherapy, suggest the possible predictive value for response to chemotherapy. PMID: 24725597
    4. Suggest CTSZ rs34069356 polymorphism is not associated with pulmonary tuberculosis in a sample Iranian population. PMID: 23827504
    5. We show that sequential cleavage of C-terminal amino acids from the beta(2) cytoplasmic tail of LFA-1, by CatX, enhances binding of the adaptor protein talin to LFA-1 and triggers formation of the latter's high-affinity form PMID: 21454358
    6. cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma PMID: 21966391
    7. cathepsin X deficiency leads to accelerated cellular senescence and consequently to diminished cellular proliferation and migration/invasion implying a potential role of cathepsin X in bypassing cellular senescence. PMID: 21616554
    8. Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility. PMID: 21368909
    9. associated with tuberculosis in a Ugandan household contact study PMID: 21354459
    10. Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin. PMID: 21310951
    11. These results show that cathepsin P, in contrast to other mammalian cathepsins, has a restricted catalytic specificity. PMID: 15680921
    12. the extracellular function of cathepsin X may include binding to integrins thereby modulating the attachment of migrating cells to ECM components [Cathepsin X] PMID: 17065156
    13. unlikely that CTSZ gene plays a major role in tuberculosis susceptibility in African populations PMID: 18420963

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  • 亚细胞定位：
    Lysosome.
  • 蛋白家族：
    Peptidase C1 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 2547

    OMIM: 603169

    KEGG: hsa:1522

    STRING: 9606.ENSP00000217131

    UniGene: Hs.252549