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CXCL3 Antibody

  • 货号：
    CSB-PA08999A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA08999A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CXCL3 Polyclonal antibody
  • Uniprot No.：
    P19876
  • 基因名：
  • 别名：
    C-X-C motif chemokine 3 antibody; C-X-C motif chemokine ligand 3 antibody; Chemokine (C X C motif) ligand 3 antibody; Chemokine (CXC motif) ligand 3 antibody; Cinc 2 antibody; CINC 2b antibody; Cinc2 antibody; CINC2b antibody; CXCL 3 antibody; Cxcl3 antibody; CXCL3_HUMAN antibody; Cytokine induced neutrophil chemoattractant 2 antibody; Dcip1 antibody; Dendritic cell inflammatory protein 1 antibody; Gm1960 antibody; GRO protein gamma antibody; GRO-gamma antibody; GRO-gamma(1-73) antibody; GRO-gamma(5-73) antibody; GRO3 antibody; GRO3 oncogene antibody; GROG antibody; Growth regulated protein gamma antibody; Growth-regulated protein gamma antibody; Macrophage inflammatory protein 2 beta precursor antibody; Macrophage inflammatory protein 2-beta antibody; Melanoma growth stimulatory activity gamma antibody; Member 3 antibody; MGSA gamma antibody; MIP 2b antibody; MIP2-beta antibody; MIP2B antibody; SCYB3 antibody; Small inducible cytokine subfamily B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human C-X-C motif chemokine 3 protein (35-107AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CXCL3 Antibody (CSB-PA08999A0Rb)，的标记方式是Non-conjugated。对于CXCL3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA08999B0Rb CXCL3 Antibody, HRP conjugated ELISA
    FITC CSB-PA08999C0Rb CXCL3 Antibody, FITC conjugated
    Biotin CSB-PA08999D0Rb CXCL3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.
  • 基因功能参考文献：
    1. CXCL3 exerts its carcinogenic potential by directly and/or indirectly regulating the downstream signaling pathways and the expression of transcription factors in PCa. PMID: 29524043
    2. Exogenous CXCL3 induced Erk1/2 and ETS1 phosphorylation and promoted CD133 expression. PMID: 27255419
    3. Our findings suggest that CXCL3 and its receptor CXCR2 are overexpressed in prostate cancer cells, prostate epithelial cells and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis. PMID: 26837773
    4. results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy PMID: 24605943
    5. CXCL3 displays antimicrobial activity against E. coli and S. aureus. PMID: 12949249
    6. secreted growth-regulated oncogene chemokines, specifically GRO-gamma, in human Mesenchymal stromal cell-conditioned media have an effect on the differentiation and the function of human monocyte-derived dendritic cells. PMID: 23589610
    7. Data show that mesenchymal stem cells (MSCs) directly regulate T cell proliferation by induction of CXCL3 chemokine and its receptor, CXCR2 on the surface in T cells. PMID: 23023221
    8. demonstrates, for the first time, that BIRC3 (anti-apoptotic protein), COL3A1 (matrix protein synthesis), and CXCL3 (chemokine) were up-regulated in the thrombin-stimulated human umbilical vein endothelial cells PMID: 16356540
    9. GRO-gamma is a promising candidate for Th2-associated glomerular permeability factor in minimal change disease. PMID: 17389786
    10. Inhibition of ERK phosphorylation decreased expression of GRO3. PMID: 17466952
    11. Report gonadotropin-releasing hormone-regulated CXCL3 expression in human placentation. PMID: 19369450
    12. propose that chemokines belonging to the CXC family could play an important role in the etiology of tendon xanthoma (TX), with CXCL3 being a possible biological marker of onset and development of TX PMID: 19448742
    13. overexpression of CXCL13 in the intestine during inflammatory conditions favors mobilization of B cells and of LTi and NK cells with immunomodulatory and reparative functions. PMID: 19741597

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine alpha (chemokine CxC) family
  • 数据库链接：

    HGNC: 4604

    OMIM: 139111

    KEGG: hsa:2921

    STRING: 9606.ENSP00000296026

    UniGene: Hs.89690