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  4. Human C-X-C motif chemokine 3(CXCL3) ELISA kit

Human C-X-C motif chemokine 3(CXCL3) ELISA kit

  • 中文名称：
    人C-X-C趋化因子3(CXCL3)酶联免疫试剂盒
  • 货号：
    CSB-EL006249HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Human CXCL3 ELISA Kit was designed for the quantitative measurement of Human CXCL3 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 9.37 pg/mL-600 pg/mL and the sensitivity is 2.34 pg/mL .

  • 别名：
    C-X-C motif chemokine 3 ELISA Kit; C-X-C motif chemokine ligand 3 ELISA Kit; Chemokine (C X C motif) ligand 3 ELISA Kit; Chemokine (CXC motif) ligand 3 ELISA Kit; Cinc 2 ELISA Kit; CINC 2b ELISA Kit; Cinc2 ELISA Kit; CINC2b ELISA Kit; CXCL 3 ELISA Kit; Cxcl3 ELISA Kit; CXCL3_HUMAN ELISA Kit; Cytokine induced neutrophil chemoattractant 2 ELISA Kit; Dcip1 ELISA Kit; Dendritic cell inflammatory protein 1 ELISA Kit; Gm1960 ELISA Kit; GRO protein gamma ELISA Kit; GRO-gamma ELISA Kit; GRO-gamma(1-73) ELISA Kit; GRO-gamma(5-73) ELISA Kit; GRO3 ELISA Kit; GRO3 oncogene ELISA Kit; GROG ELISA Kit; Growth regulated protein gamma ELISA Kit; Growth-regulated protein gamma ELISA Kit; Macrophage inflammatory protein 2 beta precursor ELISA Kit; Macrophage inflammatory protein 2-beta ELISA Kit; Melanoma growth stimulatory activity gamma ELISA Kit; Member 3 ELISA Kit; MGSA gamma ELISA Kit; MIP 2b ELISA Kit; MIP2-beta ELISA Kit; MIP2B ELISA Kit; SCYB3 ELISA Kit; Small inducible cytokine subfamily B ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    9.37 pg/mL-600 pg/mL
  • 灵敏度：
    2.34 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human CXCL3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %90
    Range %87-93
    1:2Average %100
    Range %97-103
    1:4Average %95
    Range %92-97
    1:8Average %99
    Range %95-102
  • 回收率：
    The recovery of human CXCL3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9491-97
    EDTA plasma (n=4)9793-99
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    6002.943 2.888 2.916 2.764
    3002.188 2.299 2.244 2.092
    1501.458 1.392 1.425 1.273
    750.778 0.790 0.784 0.632
    37.50.392 0.382 0.387 0.235
    18.750.288 0.269 0.279 0.127
    9.370.240 0.234 0.237 0.085
    00.153 0.151 0.152 　
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.
  • 基因功能参考文献：
    1. CXCL3 exerts its carcinogenic potential by directly and/or indirectly regulating the downstream signaling pathways and the expression of transcription factors in PCa. PMID: 29524043
    2. Exogenous CXCL3 induced Erk1/2 and ETS1 phosphorylation and promoted CD133 expression. PMID: 27255419
    3. Our findings suggest that CXCL3 and its receptor CXCR2 are overexpressed in prostate cancer cells, prostate epithelial cells and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis. PMID: 26837773
    4. results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy PMID: 24605943
    5. CXCL3 displays antimicrobial activity against E. coli and S. aureus. PMID: 12949249
    6. secreted growth-regulated oncogene chemokines, specifically GRO-gamma, in human Mesenchymal stromal cell-conditioned media have an effect on the differentiation and the function of human monocyte-derived dendritic cells. PMID: 23589610
    7. Data show that mesenchymal stem cells (MSCs) directly regulate T cell proliferation by induction of CXCL3 chemokine and its receptor, CXCR2 on the surface in T cells. PMID: 23023221
    8. demonstrates, for the first time, that BIRC3 (anti-apoptotic protein), COL3A1 (matrix protein synthesis), and CXCL3 (chemokine) were up-regulated in the thrombin-stimulated human umbilical vein endothelial cells PMID: 16356540
    9. GRO-gamma is a promising candidate for Th2-associated glomerular permeability factor in minimal change disease. PMID: 17389786
    10. Inhibition of ERK phosphorylation decreased expression of GRO3. PMID: 17466952
    11. Report gonadotropin-releasing hormone-regulated CXCL3 expression in human placentation. PMID: 19369450
    12. propose that chemokines belonging to the CXC family could play an important role in the etiology of tendon xanthoma (TX), with CXCL3 being a possible biological marker of onset and development of TX PMID: 19448742
    13. overexpression of CXCL13 in the intestine during inflammatory conditions favors mobilization of B cells and of LTi and NK cells with immunomodulatory and reparative functions. PMID: 19741597

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine alpha (chemokine CxC) family
  • 数据库链接：

    HGNC: 4604

    OMIM: 139111

    KEGG: hsa:2921

    STRING: 9606.ENSP00000296026

    UniGene: Hs.89690