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CUL5 Antibody

  • 货号：
    CSB-PA835890ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA835890ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA835890ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CUL5 Polyclonal antibody
  • Uniprot No.：
    Q93034
  • 基因名：
  • 别名：
    CUL 5 antibody; CUL-5 antibody; CUL5 antibody; CUL5_HUMAN antibody; Cullin 5 antibody; Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1) antibody; Cullin-5 antibody; Cullin5 antibody; VACM 1 antibody; VACM-1 antibody; VACM1 antibody; Vasopressin activated calcium mobilizing receptor 1 antibody; Vasopressin activated calcium mobilizing receptor antibody; Vasopressin-activated calcium-mobilizing receptor 1 antibody; Vasopressin-activated calcium-mobilizing receptor-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cullin-5 protein (1-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. ECS(KLHDC1) complex is part of the DesCEND (destruction via C-end degrons) pathway and mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine. May form a cell surface vasopressin receptor.; (Microbial infection) Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein.
  • 基因功能参考文献：
    1. CUL5 may be an important part of the mechanism for thalidomide-dependent inhibition. PMID: 29746508
    2. These findings report genetic variants possibly associated with susceptibility to HIV-1 infection (CUL5 rs11212495, rs7103534, rs7117111) and partial viral load control (APOBEC3G rs2294367). PMID: 28302043
    3. structural model suggests that the diverse FIV and HIV-1 Vifs use conserved residues for Cullin 5 binding, FIV Vif binds Cullin 5 independently of zinc, in contrast to HIV-1 Vif. PMID: 29263270
    4. these findings identify Cul-5 as a signaling component that connects an LPS-activated TLR4-MyD88 complex to TRAF6 for efficient activation of NF-kappaB PMID: 27233966
    5. CUL5 neddylation may allosterically tune polyubiquitin chain length and topology. PMID: 28082425
    6. Study found that CUL5 expression was significantly decreased in both endometrioid adenocarcinomas with the more aggressive serous type displaying a higher reduction. Its mRNA and protein overexpression in endometrial cancer cells resulted in decreased cell proliferation. PMID: 26847831
    7. Studies indicate that Cullin-RING E3 ubiquitin ligases (CRL) are key players of the ubiquitylation pathway. PMID: 26253693
    8. These results provide important information on the assembly of the Vif-CUL5-E3 ubiquitin ligase and identify a new viV binding interface with CBF-beta at the C-terminus of HIV-1 Vif. PMID: 25424878
    9. Data indicate that cell surface adhesion molecules VCAM-1 and P-selectin play some roles in mechanical stretch-induced HL-60 cell adhesion to mouse common carotid arteries. PMID: 25108430
    10. N-terminal mutants of HIV-1 vif that demonstrated reduced Cul5 binding were also unable to degrade APOBEC3G as well as APOBEC3F. PMID: 24422669
    11. A tumor suppressor gene, CUL5, is identified as a direct target of miR-7 in hepatocellular carcinoma. PMID: 24339204
    12. Silencing CUL5 reduced cellular sensitivity to three distinct HSP90 inhibitors, across four cancer types driven by different protein kinases. PMID: 24760825
    13. In the absence of CBFbeta, Vif does not bind Cul5, thus preventing the assembly of the E3 ligase complex. PMID: 24390320
    14. CBF-beta is critical for the formation of the Vif-ElonginB/ElonginC-Cul5 core E3 ubiquitin ligase complex. PMID: 24390335
    15. data reveal the structural basis for Vif hijacking of the CBF-beta and CUL5 E3 ligase complex, laying a foundation for rational design of novel anti-HIV drugs PMID: 24402281
    16. ASB9 is unstable alone but forms a stable ternary complex with EloBC that binds with high affinity to the Cullin 5 N-terminal domain. PMID: 23837592
    17. crystal structure shows interaction between SOCS2-elongin BC and Cullin-5 PMID: 23897481
    18. Data indicate tht n the Biaka, strong signal of selection was detected at CUL5 and at TSG101. PMID: 23217182
    19. comparison of heat capacity changes supports a model in which CBFbeta prestabilizes Vif((1-192)) relative to Vif((95-192)), consistent with a stronger interaction of Cul5 with Vif's C-terminal Zn(2+)-binding motif. PMID: 23098073
    20. detected a reduced editing associated with the CUL5 SNP6 minor allele and also with certain Vif variants (mutations at sites 46, 122, and 160). PMID: 22145963
    21. Vif alterations may contribute to a rapid AIDS onset and Vif variability could be influenced by APOBEC3G and CUL5 polymorphisms in children PMID: 21571098
    22. study showed VACM-1 DNA in T47D cancer cells is not mutated; SNP found in U138MG, OVCAR-3 and ACHN cell lines results in silent mutation; results suggest in T47D cancer cells, VACM-1 activity may controlled by epigenetic or posttranslational modification PMID: 21635549
    23. Cul5 interacts with the Hsp90 chaperone complex and is recruited to the site of ErbB2 on the plasma membrane, thereby inducing its polyubiquitination and proteasome-mediated degradation. PMID: 19933325
    24. findings report that HIV-1 Vif interacts with cellular proteins Cul5, elongins B and C, and Rbx1 to form an Skp1-cullin-F-box (SCF)-like complex PMID: 14564014
    25. These data indicate that vasopressin-activated calcium-mobilizing (VACM-1) is involved in the regulation of cellular growth. PMID: 15184056
    26. Cul5 promotes vif ubiquination and requires intact SOCS-box PMID: 15574592
    27. the E3 ubiquitin ligase activity of the Vif-BC-Cul5 complex is essential for Vif function against APOBEC3G PMID: 15781449
    28. findings indicate that the assembly of Vif-Cul5 E3 ubiquitin ligases requires a hydrophobic interface within a novel zinc-binding domain in the substrate receptor Vif and a unique region in Cul5 PMID: 16530799
    29. the zinc-binding region in Vif is a novel cullin interaction domain that mediates selective binding to Cul5 PMID: 16636053
    30. Data indicate that in the T47D cancer cell line VACM-1 inhibits growth by attenuating estrogen-dependent/estrogen receptor alpha signaling responses. PMID: 17186378
    31. Adenovirus E4orf6-mediated p53 degradation requires Cul5. PMID: 17351129
    32. CUL5, together with NPAT and PPP2R1B, is implicated in the deregulation of the cell-cycle and apoptosis regulators and in the pathogenesis of B-CLL. PMID: 17449237
    33. Cul5 plays an essential role in regulating neuron migrations during cortical development, possibly by opposing a promigratory effect of Dab1. PMID: 17974915
    34. Degradation of AAV5 proteins can be inhibited by a dominant-negative ubiquitin that prevents chain elongation or by small interfering RNA directed against cullin 5. PMID: 18216112
    35. The purpose of this study was to determine if there is increased expression of Cul5 during granulocytic differentiation of HL-60 cells. PMID: 19118439
    36. HIV-1 virion infectivity factor (Vif) protein-cullin 5 (Cul5) interaction is mediated by zinc binding to the conserved Vif HCCH motif. Zinc enhances the Vif HCCH-Cul5 interaction by 8-fold. PMID: 19588889

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  • 蛋白家族：
    Cullin family
  • 数据库链接：

    HGNC: 2556

    OMIM: 601741

    KEGG: hsa:8065

    STRING: 9606.ENSP00000376808

    UniGene: Hs.440320