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CTSV Antibody

  • 货号：
    CSB-PA006194ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: CTSV antibody at 12μg/ml
      Lane 1: Jurkat whole cell lysate
      Lane 2: MCF-7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 37 kDa
      Observed band size: 37 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006194ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA006194ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CTSV Polyclonal antibody
  • Uniprot No.：
    O60911
  • 基因名：
  • 别名：
    CAT L2 antibody; Cathepsin L2 antibody; Cathepsin U antibody; Cathepsin V antibody; CathepsinL2 antibody; CathepsinU antibody; CathepsinV antibody; CATL 2 antibody; CATL2 antibody; CATL2_HUMAN antibody; CTS L2 antibody; CTS U antibody; CTS V antibody; CTSL 2 antibody; CTSL2 antibody; CTSU antibody; CTSV antibody; MGC125957 antibody; PRO305 antibody; UNQ268 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cathepsin L2 protein (105-334AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cysteine protease. May have an important role in corneal physiology.
  • 基因功能参考文献：
    1. CTSV is involved in melanosome degradation. PMID: 29654760
    2. exogenous CTSV inhibited Ang -induced hypertrophy in HCM cells by inhibiting PI3K/Akt/mTOR PMID: 28522343
    3. Cathepsins V and S may serve as auxiliary diagnostic and/or prognostic markers in thymic epithelial tumors. PMID: 27771373
    4. E2F1 directly binds to CTSL2 promoter and regulates CTSL2 gene expression. PMID: 23542171
    5. using cathepsin V and cathepsin L as model enzymes, a series of chimeras were generated to identify noncatalytic regions that are responsible for the potent elastolytic activity of cathepsin V PMID: 24121514
    6. Cathepsin V expression contributes to the development of dermal fibrosis and vasculopathy in systemic sclerosis. PMID: 23287360
    7. functions of cathepsin V are controlled by N-glycosylation PMID: 22967898
    8. Findings indicate the unique function of cathepsin V for producing enkephalin and neuropeptide Y (NPY) neuropeptides required for neurotransmission in health and neurological diseases. PMID: 22393040
    9. CTSL2 might be involved in progression of endometrial cancer. PMID: 22452389
    10. A proteolytically active variant of cathepsin V is localized to cell nucleus (in peri-nucleolar pattern) in thyroid carcinoma cells. PMID: 20536394
    11. stratum corneum thiol protease is identical with the recently described cathepsin L2 protease. PMID: 12648222
    12. Cathepsin V is involved in the degradation of invariant chain in human thymus PMID: 12925692
    13. Cathepsin V has an elastolytic activity and is expressed in activated macrophages PMID: 15192101
    14. Human cathepsin V compensates for murine cathepsin L in mouse epidermis and hair follicles. PMID: 15679121
    15. propeptide was found to behave as a tight-binding inhibitor against CatV PMID: 17516850
    16. Associated with type 1 diabetes and early-onset myasthenia gravis. PMID: 17869649
    17. angiogenesis inhibition activity on endothelial cells caused by plasminogen processing by cathepsin V PMID: 18163891

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  • 亚细胞定位：
    Lysosome.
  • 蛋白家族：
    Peptidase C1 family
  • 组织特异性：
    Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.
  • 数据库链接：

    HGNC: 2538

    OMIM: 603308

    KEGG: hsa:1515

    STRING: 9606.ENSP00000259470

    UniGene: Hs.610096