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  4. Recombinant Human Cathepsin L2 (CTSL2)

Recombinant Human Cathepsin L2 (CTSL2)

  • 货号：
    CSB-YP006194HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP006194HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP006194HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP006194HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP006194HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CAT L2; Cathepsin L2; Cathepsin U; Cathepsin V; CathepsinL2; CathepsinU; CathepsinV; CATL 2; CATL2; CATL2_HUMAN; CTS L2; CTS U; CTS V; CTSL 2; CTSL2; CTSU; CTSV; MGC125957; PRO305; UNQ268
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    114-334
  • 氨基酸序列
    LPKSVDW RKKGYVTPVK NQKQCGSCWA FSATGALEGQ MFRKTGKLVS LSEQNLVDCS RPQGNQGCNG GFMARAFQYV KENGGLDSEE SYPYVAVDEI CKYRPENSVA NDTGFTVVAP GKEKALMKAV ATVGPISVAM DAGHSSFQFY KSGIYFEPDC SSKNLDHGVL VVGYGFEGAN SNNSKYWLVK NSWGPEWGSN GYVKIAKDKN NHCGIATAAS YPNV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cysteine protease. May have an important role in corneal physiology.
  • 基因功能参考文献：
    1. CTSV is involved in melanosome degradation. PMID: 29654760
    2. exogenous CTSV inhibited Ang -induced hypertrophy in HCM cells by inhibiting PI3K/Akt/mTOR PMID: 28522343
    3. Cathepsins V and S may serve as auxiliary diagnostic and/or prognostic markers in thymic epithelial tumors. PMID: 27771373
    4. E2F1 directly binds to CTSL2 promoter and regulates CTSL2 gene expression. PMID: 23542171
    5. using cathepsin V and cathepsin L as model enzymes, a series of chimeras were generated to identify noncatalytic regions that are responsible for the potent elastolytic activity of cathepsin V PMID: 24121514
    6. Cathepsin V expression contributes to the development of dermal fibrosis and vasculopathy in systemic sclerosis. PMID: 23287360
    7. functions of cathepsin V are controlled by N-glycosylation PMID: 22967898
    8. Findings indicate the unique function of cathepsin V for producing enkephalin and neuropeptide Y (NPY) neuropeptides required for neurotransmission in health and neurological diseases. PMID: 22393040
    9. CTSL2 might be involved in progression of endometrial cancer. PMID: 22452389
    10. A proteolytically active variant of cathepsin V is localized to cell nucleus (in peri-nucleolar pattern) in thyroid carcinoma cells. PMID: 20536394
    11. stratum corneum thiol protease is identical with the recently described cathepsin L2 protease. PMID: 12648222
    12. Cathepsin V is involved in the degradation of invariant chain in human thymus PMID: 12925692
    13. Cathepsin V has an elastolytic activity and is expressed in activated macrophages PMID: 15192101
    14. Human cathepsin V compensates for murine cathepsin L in mouse epidermis and hair follicles. PMID: 15679121
    15. propeptide was found to behave as a tight-binding inhibitor against CatV PMID: 17516850
    16. Associated with type 1 diabetes and early-onset myasthenia gravis. PMID: 17869649
    17. angiogenesis inhibition activity on endothelial cells caused by plasminogen processing by cathepsin V PMID: 18163891

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  • 亚细胞定位：
    Lysosome.
  • 蛋白家族：
    Peptidase C1 family
  • 组织特异性：
    Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.
  • 数据库链接：

    HGNC: 2538

    OMIM: 603308

    KEGG: hsa:1515

    STRING: 9606.ENSP00000259470

    UniGene: Hs.610096