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CSH1 Antibody

  • 货号：
    CSB-PA077659
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA077659(CSH1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA077659(CSH1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human placenta tissue, Human breast infiltrative duct tissue, Primary antibody: CSB-PA077659(CSH1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P0DML2
  • 基因名：
  • 别名：
    CSH1Chorionic somatomammotropin hormone 1 antibody; Choriomammotropin antibody; Lactogen antibody; Placental lactogen antibody; PL antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human CSH1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.
  • 基因功能参考文献：
    1. FGF-2b and hPL-A are promising candidates for regenerative therapy in Diabetes Mellitus by inducing de-differentiation of stem cells modulating pivotal endocrine genes. PMID: 29068419
    2. Placental lactogen is expressed but is not translated into protein in breast cancer. PMID: 24475273
    3. These results indicate that placental lactogen induces CYP2E1 expression via PI3-kinase pathway in human hepatocytes. PMID: 24408518
    4. Expression of placental lactogen mRNA is increased in plasma of women with placenta previa and invasive placenta. PMID: 23744883
    5. altered expression of placenta lactogen appears not to be causal for betamethasone-induced fetal growth restriction in the human PMID: 23465880
    6. results are consistent with a pleiotropic effect of placental hGH/CSH genes at the maternal-fetal interface relating to the regulation of fetal growth and the risk of affected maternal metabolism. PMID: 22387044
    7. Data conclude that members of the C/EBP and Ets families can differentially modulate CS-Benh and CS-Aenh activity. PMID: 21737519
    8. hPL-A is involved in the regulation of pancreatic beta cells activity. PMID: 21765243
    9. Results strongly support a conformationally mediated obligate-ordered prolactin receptor binding for each of the three lactogenic hormones: prolactin, growth hormone, and placental lactogen. PMID: 20427283
    10. The human growth hormone/chorionic somatomammotropin at chromosome 17 is implicated in regulation of postnatal and intrauterine growth. PMID: 20233782
    11. Investigation of the GRB2, GRB7, and CSH1 genes as candidates for the Silver-Russell syndrome (SRS) on chromosome 17q. PMID: 11897833
    12. a role for CSH1 haploinsufficiency in the etiology of growth retardation PMID: 14642004
    13. These data implicate ETS-domain family members in the regulation of the CS locus in placenta and pituitary cells. PMID: 14673137
    14. We showed that intra-arterial infusion of human placental lactogen primarily decreased coronary, renal & iliac blood flow. Mechanism of this response was shown to be due to inhibition of vasodilatory beta2-adrenergic receptor-mediated effect. PMID: 16410683
    15. crystal structure of the free state of human PL has been determined to 2.0 A resolution showing the molecule possesses an overall structure similar to other long chain four-helix bundle cytokines PMID: 16546209
    16. The present findings indicate that the concentration of human placental lactogen (hPL) and human chorionic gonadotropin (beta hCG) mRNA is significantly higher in the cellular component of maternal blood samples than in the plasma component. PMID: 16950818
    17. A CSH1 deletion carrier with nearly complete hypomethylation at the ICR1 locus had the characteristic clinical signs of Silver Russel syndrome, ruling out a causal relationship. PMID: 17400796
    18. Placental lactogen is a novel ligand of stabilin-1. PMID: 18292525
    19. Three single nucleotide polymorphisms in CGB5 and CSH1 genes were genotyped for 844 offspring of the cases and controls. Maternal breast cancer risk did not significantly differ by the offspring's carrier status of the three SNPs. PMID: 19047151
    20. maternal smoking associated with a reduction in cord blood hPL PMID: 19290844

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Somatotropin/prolactin family
  • 数据库链接：

    HGNC: 2440

    OMIM: 150200

    KEGG: hsa:1442

    STRING: 9606.ENSP00000316416

    UniGene: Hs.654390