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COX18 Antibody

  • 货号：
    CSB-PA005830GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8N8Q8
  • 基因名：
    COX18
  • 别名：
    COX18 antibody; COX18 cytochrome c oxidase assembly homolog (S. cerevisiae) antibody; COX18_HUMAN antibody; COX18Hs antibody; Cox18Hs1 protein antibody; Cox18Hs2 protein antibody; Cox18Hs3 protein antibody; Cytochrome c oxidase assembly homolog (S. cerevisiae) antibody; Cytochrome c oxidase assembly protein 18 antibody; FLJ38991 antibody; MGC126733 antibody; Mitochondrial COX18 antibody; Mitochondrial inner membrane protein COX18 antibody; OXA1L2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human COX18
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase).
  • 基因功能参考文献：
    1. COX20 stabilizes COX2 during insertion of its N-proximal transmembrane domain, and subsequently, COX18 transiently interacts with COX2 to promote translocation across the inner membrane of the COX2 C-tail that contains the apo-CuA site. The release of COX18 from this complex coincides with the binding of the SCO1-SCO2-COA6 copper metallation module to COX2-COX20 to finalize COX2 biogenesis. PMID: 28330871
    2. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20819778
    3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20200953
    6. COX18 mutations may be very rare or associated with other phenotypes than isolated COX deficiency in infancy. PMID: 19373256
    7. Both hCox18p and hCox19p present significant amino acid identity with the corresponding yeast polypeptides and reveal highly conserved functional domains. PMID: 16212937

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  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    OXA1/ALB3/YidC family
  • 数据库链接：

    HGNC: 26801

    OMIM: 610428

    KEGG: hsa:285521

    STRING: 9606.ENSP00000295890

    UniGene: Hs.356697