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  4. Recombinant Human Mitochondrial inner membrane protein COX18 (COX18), partial

Recombinant Human Mitochondrial inner membrane protein COX18 (COX18), partial

  • 货号：
    CSB-YP854071HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP854071HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP854071HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP854071HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP854071HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    COX18
  • Uniprot No.：
  • 别名：
    COX18; COX18 cytochrome c oxidase assembly homolog (S. cerevisiae); COX18_HUMAN; COX18Hs; Cox18Hs1 protein; Cox18Hs2 protein; Cox18Hs3 protein; Cytochrome c oxidase assembly homolog (S. cerevisiae); Cytochrome c oxidase assembly protein 18; FLJ38991; MGC126733; Mitochondrial COX18; Mitochondrial inner membrane protein COX18; OXA1L2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase).
  • 基因功能参考文献：
    1. COX20 stabilizes COX2 during insertion of its N-proximal transmembrane domain, and subsequently, COX18 transiently interacts with COX2 to promote translocation across the inner membrane of the COX2 C-tail that contains the apo-CuA site. The release of COX18 from this complex coincides with the binding of the SCO1-SCO2-COA6 copper metallation module to COX2-COX20 to finalize COX2 biogenesis. PMID: 28330871
    2. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20819778
    3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20200953
    6. COX18 mutations may be very rare or associated with other phenotypes than isolated COX deficiency in infancy. PMID: 19373256
    7. Both hCox18p and hCox19p present significant amino acid identity with the corresponding yeast polypeptides and reveal highly conserved functional domains. PMID: 16212937

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  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    OXA1/ALB3/YidC family
  • 数据库链接：

    HGNC: 26801

    OMIM: 610428

    KEGG: hsa:285521

    STRING: 9606.ENSP00000295890

    UniGene: Hs.356697