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COLEC12 Antibody

  • 货号：
    CSB-PA952749
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA952749(COLEC12 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA952749(COLEC12 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q5KU26
  • 基因名：
    COLEC12
  • 别名：
    CL P1 antibody; CL-P1 antibody; CLP1 antibody; COL12_HUMAN antibody; COLEC 12 antibody; colec12 antibody; Collectin placenta 1 antibody; Collectin placenta protein 1 antibody; Collectin sub family member 12 antibody; Collectin-12 antibody; hCL P1 antibody; hCL-P1 antibody; NSR2 antibody; Nurse cell scavenger receptor 2 antibody; SCARA4 antibody; Scavenger receptor class A member 4 antibody; Scavenger receptor with C type lectin antibody; Scavenger receptor with C-type lectin antibody; SRCL antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human COLEC12
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:30-1:150
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease.
  • 基因功能参考文献：
    1. CL-P1 is a novel receptor involved in myelin uptake by phagocytes and likely plays a role in multiple sclerosis lesion development. PMID: 28317919
    2. rs17684886 (ZNRF1) and rs599019 (COLEC12) are associated with diabetic retinopathy and rs6427247 (SCYL1BP1) and rs899036 (API5) are associated with severe diabetic retinopathy in Chinese patients with type 2 diabetes PMID: 25819896
    3. The common presence of Lewis(x) groups in granule protein glycans can thus target granule proteins for clearance by SRCL. PMID: 21561871
    4. The Le(x) residues of both, CEACAM1 and CEA, interact with the human Le(x)-binding glycan receptors DC-SIGN and SRCL. PMID: 20034698
    5. haplotype structure of the CL-P1 gene obtained from six single-nucleotide polymorphisms that were genotyped with 108 alleles in Japanese subjects PMID: 12601552
    6. SRCL is expressed in some but not all nurse-like cells; its C-type lectin domain binds specifically to several carbohydrates including GalNAc, T and Tn antigen in a Ca2+-dependent manner. PMID: 12761161
    7. SRCL might be involved in selective clearance of specific desialylated glycoproteins from circulation and/or interaction of cells bearing Lewis(x)-type structures with the vascular endothelium PMID: 15845541
    8. CL-P1 is not a common membrane protein on endothelial cells found in normal tissues under steady state conditions. PMID: 18423602
    9. CL-P1 predominantly mediated phagocytosis for fungi in vascular endothelia. PMID: 19073604

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  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein. Note=Forms clusters on the cell surface.
  • 组织特异性：
    Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed
  • 数据库链接：

    HGNC: 16016

    OMIM: 607621

    KEGG: hsa:81035

    STRING: 9606.ENSP00000383115

    UniGene: Hs.464422