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COLEC10 Antibody

  • 货号：
    CSB-PA896556LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA896556LA01HU diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA896556LA01HU diluted at 1:300 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) COLEC10 Polyclonal antibody
  • Uniprot No.：
    Q9Y6Z7
  • 基因名：
    COLEC10
  • 别名：
    CL-34 antibody; CL-L1 antibody; CLL1 antibody; COL10_HUMAN antibody; Colec10 antibody; Collectin liver 1 antibody; Collectin liver protein 1 antibody; Collectin sub family member 10 (C-type lectin) antibody; Collectin sub family member 10 antibody; Collectin subfamily member 10 antibody; Collectin-10 antibody; Collectin-34 antibody; MGC118794 antibody; MGC118795 antibody; OTTHUMP00000228058 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Collectin-10 protein (28-277AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，COLEC10 Antibody (CSB-PA896556LA01HU)，的标记方式是Non-conjugated。对于COLEC10 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA896556LB01HU COLEC10 Antibody, HRP conjugated ELISA
    FITC CSB-PA896556LC01HU COLEC10 Antibody, FITC conjugated
    Biotin CSB-PA896556LD01HU COLEC10 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Acts as a chemoattractant, probably involved in the regulation of cell migration.
  • 基因功能参考文献：
    1. High CLL1 expression is associated with cardiovascular disease. PMID: 27341702
    2. Exome sequencing reveals mutations in collectin sub-family member 10 (C-type lectin) protein (COLEC10) as a cause of 3MC syndrome with main features include facial dysmorphism, craniosynostosis and cleft lip/palate. PMID: 28301481
    3. high serum CL-L1 concentration in critically ill children upon PICU admission is associated with an increased risk of infection and prolonged need of intensive care, and counteracts the protective effect of having a high MASP-3 concentration PMID: 27057739
    4. Data indicate differences in the plasma concentrations of collectin liver 1 and collectin kidney 1, M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls. PMID: 26154564
    5. Carriers of COLEC10 Arg125Trp had increased CL-L1 serum levels. PMID: 25710878
    6. Most plasma CL-K1 was found in complex with CL-L1 in a ratio suggesting a heteromeric subunit of 1 CL-L1 & 2 CL-K1 polypeptides. PMID: 24174618

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  • 相关疾病：
    3MC syndrome 3 (3MC3)
  • 亚细胞定位：
    Secreted. Golgi apparatus. Cytoplasm.
  • 蛋白家族：
    COLEC10/COLEC11 family
  • 组织特异性：
    Highly expressed in liver, placenta and adrenal gland. Moderately expressed in small intestine, lung, stomach and prostate. Weakly expressed in trachea and spleen.
  • 数据库链接：

    HGNC: 2220

    OMIM: 248340

    KEGG: hsa:10584

    STRING: 9606.ENSP00000332723

    UniGene: Hs.176615