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Human Collectin-10(COLEC10) ELISA kit

  • 中文名称：
    人胶原凝集素-10(COLEC10)酶联免疫试剂盒
  • 货号：
    CSB-EL005760HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Human COLEC10 ELISA Kit was designed for the quantitative measurement of Human COLEC10 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 23.44 pg/mL-1500 pg/mL and the sensitivity is 5.86 pg/mL.

  • 别名：
    CL-34 ELISA Kit; CL-L1 ELISA Kit; CLL1 ELISA Kit; COL10_HUMAN ELISA Kit; Colec10 ELISA Kit; Collectin liver 1 ELISA Kit; Collectin liver protein 1 ELISA Kit; Collectin sub family member 10 (C-type lectin) ELISA Kit; Collectin sub family member 10 ELISA Kit; Collectin subfamily member 10 ELISA Kit; Collectin-10 ELISA Kit; Collectin-34 ELISA Kit; MGC118794 ELISA Kit; MGC118795 ELISA Kit; OTTHUMP00000228058 ELISA Kit
  • 缩写：
    COLEC10
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    23.44 pg/mL-1500 pg/mL
  • 灵敏度：
    5.86 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human COLEC10 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %87
    Range %81-92
    1:2Average %92
    Range %83-98
    1:4Average %97
    Range %93-101
    1:8Average %95
    Range %87-99
  • 回收率：
    The recovery of human COLEC10 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9692-102
    EDTA plasma (n=4)8882-94
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    15002.880 2.964 2.922 2.814
    7502.541 2.427 2.484 2.376
    3751.832 1.734 1.783 1.675
    187.50.997 0.972 0.985 0.877
    93.750.533 0.554 0.544 0.436
    46.880.380 0.376 0.378 0.270
    23.440.254 0.258 0.256 0.148
    00.107 0.108 0.108
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Acts as a chemoattractant, probably involved in the regulation of cell migration.
  • 基因功能参考文献：
    1. High CLL1 expression is associated with cardiovascular disease. PMID: 27341702
    2. Exome sequencing reveals mutations in collectin sub-family member 10 (C-type lectin) protein (COLEC10) as a cause of 3MC syndrome with main features include facial dysmorphism, craniosynostosis and cleft lip/palate. PMID: 28301481
    3. high serum CL-L1 concentration in critically ill children upon PICU admission is associated with an increased risk of infection and prolonged need of intensive care, and counteracts the protective effect of having a high MASP-3 concentration PMID: 27057739
    4. Data indicate differences in the plasma concentrations of collectin liver 1 and collectin kidney 1, M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls. PMID: 26154564
    5. Carriers of COLEC10 Arg125Trp had increased CL-L1 serum levels. PMID: 25710878
    6. Most plasma CL-K1 was found in complex with CL-L1 in a ratio suggesting a heteromeric subunit of 1 CL-L1 & 2 CL-K1 polypeptides. PMID: 24174618

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  • 相关疾病：
    3MC syndrome 3 (3MC3)
  • 亚细胞定位：
    Secreted. Golgi apparatus. Cytoplasm.
  • 蛋白家族：
    COLEC10/COLEC11 family
  • 组织特异性：
    Highly expressed in liver, placenta and adrenal gland. Moderately expressed in small intestine, lung, stomach and prostate. Weakly expressed in trachea and spleen.
  • 数据库链接：

    HGNC: 2220

    OMIM: 248340

    KEGG: hsa:10584

    STRING: 9606.ENSP00000332723

    UniGene: Hs.176615