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COASY Antibody

  • 货号：
    CSB-PA618754LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate
      All lanes: COASY antibody at 3.4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 63, 66 kDa
      Observed band size: 63, 66 kDa
    • Immunofluorescent analysis of Hela cells using CSB-PA618754LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) COASY Polyclonal antibody
  • Uniprot No.：
    Q13057
  • 基因名：
    COASY
  • 别名：
    Bifunctional coenzyme A synthase antibody; Bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase antibody; CoA synthase antibody; COASY antibody; COASY_HUMAN antibody; Coenzyme A synthase antibody; Dephospho-CoA kinase antibody; Dephospho-CoA pyrophosphorylase antibody; Dephosphocoenzyme A kinase antibody; DPCK antibody; DPCOAK antibody; NBP antibody; Nucleotide binding protein antibody; Pantetheine-phosphate adenylyltransferase antibody; Phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase antibody; pOV 2 antibody; POV-2 antibody; POV2 antibody; PPAT antibody; UKR1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Bifunctional coenzyme A synthase protein (453-546AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，COASY Antibody (CSB-PA618754LA01HU)，的标记方式是Non-conjugated。对于COASY Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA618754LB01HU COASY Antibody, HRP conjugated ELISA
    FITC CSB-PA618754LC01HU COASY Antibody, FITC conjugated
    Biotin CSB-PA618754LD01HU COASY Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
  • 基因功能参考文献：
    1. The recruitment of COASY inhibits CBP-mediated TPX2 acetylation, promoting TPX2 degradation for mitotic exit. PMID: 29531224
    2. The COASY protein contains a mitochondrial localization signal, a regulatory region and a domain for each of the two catalytic kinase domains: adenyl transferase and dephospho CoA PMID: 27021474
    3. DNA methylation levels in the COASY and SPINT1 promoter regions were considered to potentially be a convenient and useful biomarker for diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment. PMID: 27992572
    4. Exome sequencing revealed the presence of recessive missense mutations in COASY, encoding coenzyme A (CoA) synthase in neurodegeneration with brain iron accumulation PMID: 24360804
    5. EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies PMID: 22982864
    6. Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase). PMID: 11994049
    7. description of the existence of a novel CoA synthase isoform, which is the product of alternative splicing and possesses a 29aa extension at the N-terminus; termed it CoASy beta PMID: 16460672
    8. CoA synthase is involved in signaling events in the cell and forms a functional complex with p85alphaPI3K in vivo. PMID: 19482007

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  • 相关疾病：
    Neurodegeneration with brain iron accumulation 6 (NBIA6)
  • 亚细胞定位：
    Cytoplasm. Mitochondrion matrix.
  • 蛋白家族：
    Eukaryotic CoaD family
  • 组织特异性：
    Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liv
  • 数据库链接：

    HGNC: 29932

    OMIM: 609855

    KEGG: hsa:80347

    STRING: 9606.ENSP00000464814

    UniGene: Hs.296422