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COASY Antibody

  • 货号：
    CSB-PA005699GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • 产品描述：
    COASY抗体（辅酶A合成酶）是一种酶，在辅酶A（CoA）的生物合成中催化最后一步反应，CoA是参与多种代谢途径的关键分子。COASY与多种疾病有关，包括神经退行性疾病和癌症。
    针对COASY的抗体是一种能够特异性识别和结合COASY的蛋白质。该抗体可用于多种研究应用，如wb、免疫组化和免疫沉淀，以检测细胞和组织中COASY的表达和定位。
    针对COASY的抗体可用于研究COASY在多种生物过程和疾病中的作用，如代谢和神经退行性疾病。通过使用该抗体阻断或调节COASY活性，研究人员可以探究COASY抑制的下游效应，并可能开发针对COASY治疗疾病的新疗法。
  • Uniprot No.：
    Q13057
  • 基因名：
    COASY
  • 别名：
    Bifunctional coenzyme A synthase antibody; Bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase antibody; CoA synthase antibody; COASY antibody; COASY_HUMAN antibody; Coenzyme A synthase antibody; Dephospho-CoA kinase antibody; Dephospho-CoA pyrophosphorylase antibody; Dephosphocoenzyme A kinase antibody; DPCK antibody; DPCOAK antibody; NBP antibody; Nucleotide binding protein antibody; Pantetheine-phosphate adenylyltransferase antibody; Phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase antibody; pOV 2 antibody; POV-2 antibody; POV2 antibody; PPAT antibody; UKR1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human COASY
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
  • 基因功能参考文献：
    1. The recruitment of COASY inhibits CBP-mediated TPX2 acetylation, promoting TPX2 degradation for mitotic exit. PMID: 29531224
    2. The COASY protein contains a mitochondrial localization signal, a regulatory region and a domain for each of the two catalytic kinase domains: adenyl transferase and dephospho CoA PMID: 27021474
    3. DNA methylation levels in the COASY and SPINT1 promoter regions were considered to potentially be a convenient and useful biomarker for diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment. PMID: 27992572
    4. Exome sequencing revealed the presence of recessive missense mutations in COASY, encoding coenzyme A (CoA) synthase in neurodegeneration with brain iron accumulation PMID: 24360804
    5. EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies PMID: 22982864
    6. Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase). PMID: 11994049
    7. description of the existence of a novel CoA synthase isoform, which is the product of alternative splicing and possesses a 29aa extension at the N-terminus; termed it CoASy beta PMID: 16460672
    8. CoA synthase is involved in signaling events in the cell and forms a functional complex with p85alphaPI3K in vivo. PMID: 19482007

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  • 相关疾病：
    Neurodegeneration with brain iron accumulation 6 (NBIA6)
  • 亚细胞定位：
    Cytoplasm. Mitochondrion matrix.
  • 蛋白家族：
    Eukaryotic CoaD family
  • 组织特异性：
    Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liv
  • 数据库链接：

    HGNC: 29932

    OMIM: 609855

    KEGG: hsa:80347

    STRING: 9606.ENSP00000464814

    UniGene: Hs.296422