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CFC1 Antibody

  • 货号：
    CSB-PA120126
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA120126(CFC1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA120126(CFC1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal intestines tissue, Primary antibody: CSB-PA120126(CFC1 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    P0CG37
  • 基因名：
    CFC1
  • 别名：
    CFC 1 antibody; CFC1 antibody; CFC1_HUMAN antibody; CFC1B antibody; CR 1 antibody; Cripto 1 antibody; Cripto FRL 1 cryptic family 1 antibody; CRYPTIC antibody; Cryptic family 1 antibody; Cryptic family protein 1 antibody; Cryptic gene antibody; Cryptic protein antibody; DTGA2 antibody; FLJ77897 antibody; FRL 1 antibody; Heterotaxy 2 (autosomal dominant) antibody; HTX2 antibody; MGC133213 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human CFC1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:20-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.
  • 基因功能参考文献：
    1. The knockdown and overexpression of CFC1 were performed using a lentiviral system in NB cell lines. The overexpression of CFC1 increased sphere formation, cell growth, and colony formation. PMID: 28620148
    2. Results demonstrated that over expression of Snail suppresses Cryptic expression and confirmed that Snail directly binds to Cryptic gene promoter and regulates its expression. PMID: 27793090
    3. enhances macrophage phagocytic activity and upregulates the production of anti- and pro-inflammatory cytokines via the NF-kappaB signaling pathway PMID: 26476731
    4. Data indicate that the duplication and deletion of CFC1 protein may play key roles in the occurrence of heterotaxy syndrome. PMID: 25423076
    5. CFC1 may be involved in the etiology of non-syndromic congenital heart disease in a Chinese population. PMID: 19853937
    6. CFC1 mutations in patients with transposition of the great arteries and double-outlet right ventricle PMID: 11799476
    7. results suggest that heterozygous cryptic family 1 (CFC1) mutation may represent a genetic predisposition to biliary atresia splenic malformation syndrome PMID: 18162845
    8. Characterization of the glycosylphosphatidylinositol-anchor signal sequence of human Cryptic with a hydrophilic extension is reported. PMID: 18930707

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  • 相关疾病：
    Heterotaxy, visceral, 2, autosomal (HTX2)
  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Does not exhibit a typical GPI-signal sequence. The C-ter hydrophilic extension of the GPI-signal sequence reduces the efficiency of processing and could lead to the production of an secreted unprocessed form. This extension is found only in primates.
  • 蛋白家族：
    EGF-CFC (Cripto-1/FRL1/Cryptic) family
  • 数据库链接：

    HGNC: 18292

    OMIM: 605194

    KEGG: hsa:55997

    STRING: 9606.ENSP00000259216

    UniGene: Hs.567542