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  4. Recombinant Human Cryptic protein (CFC1)

Recombinant Human Cryptic protein (CFC1)

  • 货号：
    CSB-YP005269HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP005269HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP005269HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP005269HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP005269HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CFC1
  • Uniprot No.：
  • 别名：
    CFC 1; CFC1; CFC1_HUMAN; CFC1B; CR 1; Cripto 1; Cripto FRL 1 cryptic family 1; CRYPTIC; Cryptic family 1; Cryptic family protein 1; Cryptic gene; Cryptic protein; DTGA2; FLJ77897; FRL 1; Heterotaxy 2 (autosomal dominant); HTX2; MGC133213
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    26-158
  • 氨基酸序列
    YQREK HNGGREEVTK VATQKHRQSP LNWTSSHFGE VTGSAEGWGP EEPLPYSRAF GEGASARPRC CRNGGTCVLG SFCVCPAHFT GRYCEHDQRR SECGALEHGA WTLRACHLCR CIFGALHCLP LQTPDRCD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.
  • 基因功能参考文献：
    1. The knockdown and overexpression of CFC1 were performed using a lentiviral system in NB cell lines. The overexpression of CFC1 increased sphere formation, cell growth, and colony formation. PMID: 28620148
    2. Results demonstrated that over expression of Snail suppresses Cryptic expression and confirmed that Snail directly binds to Cryptic gene promoter and regulates its expression. PMID: 27793090
    3. enhances macrophage phagocytic activity and upregulates the production of anti- and pro-inflammatory cytokines via the NF-kappaB signaling pathway PMID: 26476731
    4. Data indicate that the duplication and deletion of CFC1 protein may play key roles in the occurrence of heterotaxy syndrome. PMID: 25423076
    5. CFC1 may be involved in the etiology of non-syndromic congenital heart disease in a Chinese population. PMID: 19853937
    6. CFC1 mutations in patients with transposition of the great arteries and double-outlet right ventricle PMID: 11799476
    7. results suggest that heterozygous cryptic family 1 (CFC1) mutation may represent a genetic predisposition to biliary atresia splenic malformation syndrome PMID: 18162845
    8. Characterization of the glycosylphosphatidylinositol-anchor signal sequence of human Cryptic with a hydrophilic extension is reported. PMID: 18930707

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  • 相关疾病：
    Heterotaxy, visceral, 2, autosomal (HTX2)
  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Does not exhibit a typical GPI-signal sequence. The C-ter hydrophilic extension of the GPI-signal sequence reduces the efficiency of processing and could lead to the production of an secreted unprocessed form. This extension is found only in primates.
  • 蛋白家族：
    EGF-CFC (Cripto-1/FRL1/Cryptic) family
  • 数据库链接：

    HGNC: 18292

    OMIM: 605194

    KEGG: hsa:55997

    STRING: 9606.ENSP00000259216

    UniGene: Hs.567542