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CDCA8 Antibody

  • 货号：
    CSB-PA005031GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q53HL2
  • 基因名：
    CDCA8
  • 别名：
    BOR antibody; BOREA_HUMAN antibody; Borealin antibody; CDCA8 antibody; Cell division cycle associated 8 antibody; cell division cycle associated protein 8 antibody; Cell division cycle-associated protein 8 antibody; Dasra B antibody; Dasra-B antibody; DasraB antibody; FLJ10468 antibody; FLJ12042 antibody; hDasra B antibody; hDasra-B antibody; MESRGP antibody; OTTHUMP00000004514 antibody; pluripotent embryonic stem cell related gene 3 protein antibody; Pluripotent embryonic stem cell-related gene 3 protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CDCA8
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
  • 基因功能参考文献：
    1. Results show that CDCA8 is overexpressed in bladder cancer (BC) and its high levels are correlated with poor clinicopathological features of BC patients. Therefore, CDCA8 may act as a novel prognostic marker in the diagnosis of patients with BC. PMID: 30142792
    2. These results were well correlated with the same gene expression pattern analysed in the thyroid tissue of the patient with BOREALIN-p.R114W. These studies open new avenues in the genetics of TD in humans. PMID: 28025328
    3. Borealin dimerization mediates chromosomal passenger complex checkpoint function by enhancing localization to centromeres and kinetochores. PMID: 25854549
    4. enhanced CDCA8 promoter activities by NF-Y overexpression and reduced CDCA8 transcription by NF-Y knockdown further verified that NF-Y is a positive regulator of CDCA8 transcription. PMID: 26170459
    5. In colorectal cancer patients, Borealin expression was positively correlated with age, lymph node metastasis and neoplasm staging. PMID: 25260804
    6. These findings reveal a previously unrecognized but direct link between HP1 and CPC localization in the centromere and illustrate the critical role of borealin-HP1 interaction in orchestrating an accurate cell division. PMID: 24917673
    7. Borealin interacts directly with the Snf7 components of ESCRT-III in human cells.the Borealin central region encompassing residues 110-207 was both necessary & sufficient to bind to CHMP4C. PMID: 22724069
    8. MLL5 functionally interacts with Borealin, facilitates the expression of chromosomal passenger complex, and hence contributes to mitotic fidelity and genomic integrity. PMID: 22797924
    9. important role for phosphorylation of Borealin at S219 in the proper progression through mitosis PMID: 20803554
    10. Data show that INCENP has an important role in stabilizing the chromosomal passenger complex, and that Borealin acts to promote binding of Survivin to INCENP. PMID: 16239925
    11. Cell cycle-regulated chromosomal passenger protein whose aberrant expression and nuclear accumulation are linked to poor prognosis for gastric cancer. PMID: 16427043
    12. A functional module within the chromosomal passenger complex involving the inner centromere protein INCENP, Survivin, and Borealin. PMID: 16571674
    13. Borealin is phosphorylated during mitosis. Neither residue S165, T106 nor phosphorylation of borealin by Aurora B Kinase is required to generate the mitotic, shifted form of Borealin. PMID: 17241471
    14. Suppression of CDCA8 expression with small interfering RNA against CDCA8 significantly suppressed the growth of lung cancer cells. PMID: 17483322
    15. It is recorded that borealin is a cell cycle regulator, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. PMID: 17716930
    16. mitotic regulator Survivin binds as a monomer to its functional interactor Borealin PMID: 17881355
    17. Borealin and INCENP associate with the helical domain of Survivin to form a tight three-helical bundle. PMID: 17956729
    18. Borealin plays a crucial role in the early mouse embryonic development PMID: 18311593
    19. Data describe a mitotic SUMO2/3 conjugation-deconjugation cycle of Borealin and further assign a regulatory function of RanBP2 and SENP3 in the mitotic SUMO pathway. PMID: 18946085
    20. found that substitutions at Borealin T230, recently identified as an Mps1 phosphorylation site, can modulate the dimerization state of Borealin PMID: 19530738

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  • 亚细胞定位：
    Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere.
  • 蛋白家族：
    Borealin family
  • 数据库链接：

    HGNC: 14629

    OMIM: 609977

    KEGG: hsa:55143

    STRING: 9606.ENSP00000316121

    UniGene: Hs.524571