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CDCA4 Antibody

  • 货号：
    CSB-PA597809
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using CDCA4 antibody.
    • Immunofluorescence analysis of HepG2 cells, using CDCA4 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CDCA4 Polyclonal antibody
  • Uniprot No.：
    Q9BXL8
  • 基因名：
    CDCA4
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human CDCA4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC,IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation.
  • 基因功能参考文献：
    1. The results confirmed that CDCA4 RNA interference reduced the percentage of human breast cancer cells to <50%. In addition, RNA interference of CDCA4 resulted in a significant increase in the apoptotic rate of cells. PMID: 29257222
    2. High CDCA4 expression is associated with malignant melanoma. PMID: 27492455
    3. CDCA4 participates in the regulation of cell proliferation, mainly through the E2F/retinoblastoma protein pathway PMID: 16984923
    4. Data suggest that CDCA4 is involved in spindle organization from prometaphase, and when anaphase begins, it may play a different role as a midzone factor involved in chromosome segregation or cytokinesis. PMID: 18498124
    5. an important role of CDCA4 in the context of transcriptional regulation and cell fate determination through the JUN oncogene PMID: 18572021
    6. Isolation of the mouse ortholog and comparison to the human protein. PMID: 11482882

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and he
  • 数据库链接：

    HGNC: 14625

    OMIM: 612270

    KEGG: hsa:55038

    STRING: 9606.ENSP00000337226

    UniGene: Hs.34045