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  4. Recombinant Human Cell division cycle-associated protein 4 (CDCA4)

Recombinant Human Cell division cycle-associated protein 4 (CDCA4)

  • 货号：
    CSB-YP874832HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP874832HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP874832HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP874832HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP874832HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CDCA4
  • Uniprot No.：
  • 别名：
    CDCA 4; Cdca4; CDCA4_HUMAN; Cell division cycle associated 4; Cell division cycle-associated protein 4; FLJ20764; FLJ52878; Hematopoietic progenitor protein; Hepp; MGC19517; SEI 3; SEI-3/HEPP; SEI3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-241
  • 氨基酸序列
    MFARGLKRKC VGHEEDVEGA LAGLKTVSSY SLQRQSLLDM SLVKLQLCHM LVEPNLCRSV LIANTVRQIQ EEMTQDGTWR TVAPQAAERA PLDRLVSTEI LCRAAWGQEG AHPAPGLGDG HTQGPVSDLC PVTSAQAPRH LQSSAWEMDG PRENRGSFHK SLDQIFETLE TKNPSCMEEL FSDVDSPYYD LDTVLTGMMG GARPGPCEGL EGLAPATPGP SSSCKSDLGE LDHVVEILVE T
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation.
  • 基因功能参考文献：
    1. The results confirmed that CDCA4 RNA interference reduced the percentage of human breast cancer cells to <50%. In addition, RNA interference of CDCA4 resulted in a significant increase in the apoptotic rate of cells. PMID: 29257222
    2. High CDCA4 expression is associated with malignant melanoma. PMID: 27492455
    3. CDCA4 participates in the regulation of cell proliferation, mainly through the E2F/retinoblastoma protein pathway PMID: 16984923
    4. Data suggest that CDCA4 is involved in spindle organization from prometaphase, and when anaphase begins, it may play a different role as a midzone factor involved in chromosome segregation or cytokinesis. PMID: 18498124
    5. an important role of CDCA4 in the context of transcriptional regulation and cell fate determination through the JUN oncogene PMID: 18572021
    6. Isolation of the mouse ortholog and comparison to the human protein. PMID: 11482882

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and he
  • 数据库链接：

    HGNC: 14625

    OMIM: 612270

    KEGG: hsa:55038

    STRING: 9606.ENSP00000337226

    UniGene: Hs.34045