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CD68 Antibody

  • 货号：
    CSB-PA282654
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA282654(CD68 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA282654(CD68 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P34810
  • 基因名：
  • 别名：
    CD68; Macrosialin; Gp110; CD antigen CD68
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human CD68
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
  • 基因功能参考文献：
    1. Combined detection of tumor-associated macrophages markers, CD68 and Sema4D, in gastric carcinoma tissue shows potential to predict the trend of gastric carcinoma progression. PMID: 29434448
    2. The study revealed that CD16-CD68-expressing macrophages appear to participate in ureteral neoplastic transformation. PMID: 29243545
    3. A combination of CD68/CD206 density and HBV-positivity improves further predictive value for post-operative recurrence of hepatocellular carcinoma (HCC) . Quantification of CD68/CD206 macrophages and their distribution can be exploited for better postsurgical management of HCC patients. PMID: 28656201
    4. Report CD68 over-expression in multinucleated giant cells and mononuclear cells in central and peripheral giant cell granuloma of jaw. PMID: 28832079
    5. This study shown the CD68 expression in Microglia and Astrocytes in stroke, Alzheimer's disease, and Lewy body dementia. PMID: 28398520
    6. The results of this study found that the expression levels of Cd68 and Atp5b were significantly correlated with the neurofibrillary tangle burden in the Alzheimer's Disease brain and with their cognition. PMID: 27911303
    7. Taken together, these results suggested that the changes, including ox-LDL/LDL ratio, CD68(+)/RANK(+) cells number, and the levels of RANKL and HMGB1 in AS patients, favored osteoclastogenesis. PMID: 29146189
    8. High expression of CD68 is associated with nonalcoholic steatohepatitis. PMID: 28951310
    9. increased amount of CD68+TAM in gaps of ductal tumor structures is protective against metastatic spread in regional lymph nodes. PMID: 26391151
    10. Most cases of histiocytic sarcoma expressed histiocytic markers CD68 (6 of 7 cases), CD163 (5 of 5 cases), and PU.1 (3 of 4 cases). PMID: 28805986
    11. Renal expression of CD68 and the chronicity index are associated with progression to chronic kidney disease in patients with proliferative lupus nephritis. PMID: 26621103
    12. Results indicate that the expression of FoxP3 was not significantly associated with survival, and suggest prognostic significance of high CD68 expression in primary central nervous system lymphoma (PCNSL). PMID: 28508176
    13. Her-2 overexpression results in ICA were similar to previous reports, the finding of 28% in HGD was unexpected and may have clinical implications. Positive Her-2 DISH in 6% of LGD is novel, suggesting a role of Her-2 during BE progression PMID: 26469325
    14. CD68 may play key roles in the pathogenesis of Alzheimer's disease (AD) and its complications may be via induction of inflammation; CD68 may be considered as a risk factor for development of AD and also psychotic symptoms in the patients PMID: 28465247
    15. hCD68GFP/ApoE(-/-) mice provide a new approach to study macrophage accumulation in atherosclerotic plaque progression and to identify cells recruited from adoptively transferred monocytes. PMID: 27908893
    16. Findings indicate that human CD68 and its mouse ortholog macrosialin located in the lysosomal membrane and share many structural similarities. PMID: 27869795
    17. The strong CD68 and S100 co-expression in our case did not allow a clear-cut discrimination between the immunophenotype of histiocytic neoplasms and amelanotic melanoma, because of CD68 immunoreactivity occurring in 75% of metastatic malignant melanomas PMID: 26407839
    18. Using double labeling with Iba-1 and cd68 could determine the physiological state of microglia in brain contusion based on their morphology and immunoreactivity. PMID: 27442380
    19. we confirmed the similarities between epithelial ovarian cancer and fallopian tube, normal and adenocarcinoma using FOLR1, FOLR2, CD68 and CD11b markers PMID: 25971554
    20. Data indicate the prognostic value of CD68 antigen in Hodgkin lymphoma (HL). PMID: 24766492
    21. This study does not support a prognostic role of CD68 positivity in predicting survival. PMID: 25204373
    22. we raised a possibility that the microlocalization of CD68(+) tumor-associated macrophages was an indispensable factor for the advance of oral squamous cell carcinoma. PMID: 25666753
    23. Data indicate that the high CD68/CD3 ratio identifies a bad prognosis group among muscle-invasive urothelial carcinoma (UC). PMID: 24794251
    24. The human CD68 promoter drives green fluorescent protein expression in all CD115(+) monocytes of adult blood, spleen, and bone marrow. PMID: 25030063
    25. CD68 tumor-associated macrophage marker is not prognostic of clinical outcome in classical Hodgkin lymphoma. PMID: 24067108
    26. The CD68-positive cells (those that have not yet developed into foam cells) present in the intima of saphenous vein grafts might serve as a very early marker of graft occlusion. PMID: 23275124
    27. the distribution of CD68-positive cells during normal brain development may not reflect a supportive role of these microglia in axonogenesis of midterm human fetuses. PMID: 24459672
    28. The MRC1/CD68 ratio is positively associated with adipose tissue lipogenesis and with muscle mitochondrial gene expression in humans. PMID: 23951013
    29. CD68 has a role in poor recurrence-free survival of hepatocellular carcinoma, but CD163 is more related to active hepatitis PMID: 23555776
    30. Multivariate analysis identified the density of CD163-positive cells as well as the ratio of CD163/CD68 expression as negative predictors for survival of epithelial ovarian cancer patients. PMID: 23289476
    31. Follicular lymphoma patients with PSMB1 P11A (G allele) and low CD68 expression have significantly longer progression free survival with bortezomib-rituximab versus rituximab. PMID: 23549871
    32. Rhinovirus colocalizes with CD68- and CD11b-positive macrophages following experimental infection in humans. PMID: 23727038
    33. the marker CD68 might accurately predict early outcome of de novo cHL and could be used in combination with c-kit and TiA1 staining. PMID: 22667341
    34. Suggest that the proteins or mRNAs expressed by the proinflammatory CD68(+)MR(-) macrophages may contribute to abdominal aortic aneurysm pathology. PMID: 23241402
    35. After bed rest, CD68 expression was increased in LBW (P=0.03) but not in NBW individuals. PMID: 22968485
    36. Increased CD68 expression was associated with Hodgkin lymphoma PMID: 22948049
    37. CSF1R and cd68 gene expression is an independent predictor for progression-free survival of Hodgkin lymphoma patients. PMID: 22955918
    38. CD163 staining is lower than CD68, with less non-specific staining of background inflammatory cells and Hodgkin cells, therefore is a better marker for Hodgkin lymphoma associated macrophages. PMID: 22289504
    39. elderly subjects had twofold higher CD68 and CD206 gene expression (both P < 0.002) than young participants. In both studies, CD68(+) muscle macrophages were not associated with BMI. PMID: 22314623
    40. CD68 may have a role in atherosclerotic plaque PMID: 22395501
    41. Statins promote the beneficial remodeling of plaques in diseased mouse arteries through the stimulation of the CCR7 / CD68 emigration pathway in macrophages PMID: 22163030
    42. CD68 and CD163 are prognostic factors for Korean patients with Hodgkin lymphoma PMID: 22044760
    43. Data show that the number of TNF-alpha and CD68 positive cells in HIZ was significantly higher than that in the annulus fibrosus around HIZ and in the control. PMID: 21192298
    44. Fibrolamellar carcinomas are positive for CD68. PMID: 21113139
    45. Increased numbers of CD68-positive tumor macrophages indicate an adverse overall outcome in Hodgkin lymphoma. PMID: 21266828
    46. Significant co-localization of CD36 receptor with cells of the macrophage lineage, such as CD68 positive cells. PMID: 20333725
    47. Treatment with etanercept may be involved in vascular and cell proliferations with inhibition of the expression of CD68 and MMP-3 in synovium of rheumatoid arthritis patients. PMID: 20374310
    48. CD68 was expressed in beta-cells of NOD mice by 14-17 weeks of age, when a large proportion of these cells were infiltrated with lymphocytes and monocytes. PMID: 12397372
    49. CD68 expression is down-regulated in lymphoid cells by combinatorial interactions between PU.1 and IRF-4 PMID: 12676954
    50. study expands the immunophenotype of granular cell tumor (S100, CD68, protein gene product 9.5, and inhibin-alpha) regardless of location and supports a neural origin PMID: 15214825

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  • 亚细胞定位：
    [Isoform Short]: Cell membrane; Single-pass type I membrane protein.; [Isoform Long]: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    LAMP family
  • 组织特异性：
    Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their diss
  • 数据库链接：

    HGNC: 1693

    OMIM: 153634

    KEGG: hsa:968

    STRING: 9606.ENSP00000250092

    UniGene: Hs.647419