产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) CD3EAP Polyclonal antibody
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Uniprot No.:O15446
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基因名:CD3EAP
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别名:A34.5 antibody; Anti sense to ERCC 1 protein antibody; Antisense to ERCC-1 protein antibody; ASE 1 antibody; ASE-1 antibody; ASE1 antibody; CAST antibody; CD3 epsilon associated protein antibody; CD3-epsilon-associated protein antibody; CD3E antigen, epsilon polypeptide associated protein antibody; CD3E associated protein antibody; CD3e molecule, epsilon associated protein antibody; CD3E-associated protein antibody; CD3EAP antibody; DNA directed RNA polymerase I subunit RPA34 antibody; DNA-directed RNA polymerase I subunit RPA34 antibody; MGC118851 antibody; PAF 49 antibody; PAF49 antibody; RNA polymerase I associated factor PAF49 antibody; RNA polymerase I-associated factor PAF49 antibody; RPA34_HUMAN antibody
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宿主:Rabbit
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反应种属:Human, Rat
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免疫原:Recombinant Human DNA-directed RNA polymerase I subunit RPA34 protein (289-404AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,CD3EAP Antibody (CSB-PA004932LA01HU),的标记方式是Non-conjugated。对于CD3EAP Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, WB, IHC, IF
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:5000 IHC 1:20-1:200 IF 1:50-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
引用文献
- STAT3 potentiates RNA polymerase I-directed transcription and tumor growth by activating RPA34 expression C Zhang,British journal of cancer,2023
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靶点详情
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功能:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation.; Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex.
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基因功能参考文献:
- Haplotypes consisting of PPP1R13L, CD3EAP and GLTSCR1 SNPs on Chr19q13.3 may associate with lung cancer risk in the Chinese population. PMID: 30128886
- a genetic variant in the CD3EAP gene is associated with outcome of patients treated for multiple myeloma PMID: 26568154
- These findings demonstrate that 19p13.3-GADD45B rs7354 variant and interaction between 19p13.3-GADD45B rs3783501 and 19q13.3-CD3EAP rs967591 may play a role in association with smoke-exposed lung cancer among Chinese. PMID: 28870783
- There was no interaction between NFKB1 polymorphisms and PPP1R13L and CD3EAP and smoking status in relation to lung cancer risk PMID: 25917613
- In nonsmoking Chinese women CD3EAP rs967591 variant allele carriers are at increased risk of lung cancer. PMID: 23624123
- Polymorphism in RAI and CD3EAP are associated with outcome of myeloma patients treated with high dose treatment. PMID: 21046104
- model for CAST/hPAF49 function in which the network of interactions of Pol I-specific subunits with UBF facilitates conformational changes of the polymerase, leading to stabilization of the Pol I-template complex and, thereby, activation of transcription PMID: 16809778
- The ASE-1 polymorphism was associated with an increased risk of adenomas, OR of 1.39 (95% CI 1.06-1.81), which upon stratification was apparent among women only, OR of 1.66 (95% CI 1.15-2.39) PMID: 16817948
- ASE-1 polymorphisms and the previously identified ASE-1 haplotype are not associated with risk of colorectal cancer. PMID: 18289367
- A SNP in the 5' noncoding region of exon 1 at position -21 from the first codon, which does not affect the final AA sequence but may affect transcription/translation, was associated with drug sensitivity in the NC160 human cancer cell line panel. PMID: 19396015
- ASE-1 co-localises with the RNA polymerase I transcription initiation factor UBF/NOR-90 throughout all stages of the cell cycle and these two proteins associate with each other in vitro. PMID: 9426281
收起更多
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亚细胞定位:Nucleus, nucleolus. Chromosome. Note=Found at the fibrillar centers of the nucleolus in interphase and during cell division it is localized to the nucleolus organizer regions of the chromosomes.
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蛋白家族:Eukaryotic RPA34 RNA polymerase subunit family
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数据库链接:
HGNC: 24219
OMIM: 107325
KEGG: hsa:10849
STRING: 9606.ENSP00000310966
UniGene: Hs.710495