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CCT5 Antibody

  • 货号：
    CSB-PA004862ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: CCT5 antibody at 1.78µg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: Colo320 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 60, 50 kDa
      Observed band size: 60 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA004862ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA004862ESR1HU at dilution of 1:100
    • Immunoprecipitating CCT5 in Hela whole cell lysate
      Lane 1: Rabbit control IgG (1µg) instead of CSB-PA004862ESR1HU in Hela whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA004862ESR1HU (8µg) + Hela whole cell lysate (500µg)
      Lane 3: Hela whole cell lysate (10µg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CCT5 Polyclonal antibody
  • Uniprot No.：
    P48643
  • 基因名：
    CCT5
  • 别名：
    CCT 5 antibody; CCT epsilon antibody; CCT-epsilon antibody; CCT5 antibody; CCTE antibody; CCTepsilon antibody; Chaperonin containing T-complex polypeptide 1; subunit 5 antibody; Chaperonin containing TCP 1 epsilon antibody; Chaperonin containing TCP 1 subunit 5 antibody; Chaperonin containing TCP 1 subunit 5 epsilon antibody; Chaperonin containing TCP1 epsilon antibody; Chaperonin containing TCP1 subunit 5 antibody; Chaperonin containing TCP1 subunit 5 epsilon antibody; KIAA0098 antibody; T complex protein 1 epsilon subunit antibody; T complex protein 1 subunit epsilon antibody; T-complex protein 1 subunit epsilon antibody; TCP 1 epsilon antibody; TCP-1-epsilon antibody; TCP1epsilon antibody; TCPE antibody; TCPE_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human T-complex protein 1 subunit epsilon protein (1-270AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
  • 基因功能参考文献：
    1. CCT5 complex caps mutant mHTT fibrils at their tips and encapsulates mHTT oligomers, providing a structural description of the inhibition of mHTTQ46-Ex1 by CCT5 complex and a shared mechanism of mHTT inhibition between TRiC chaperonin and the CCT5 complex PMID: 25995452
    2. H147R CCT5 was not as efficient in chaperoning these substrates as wild type CCT5. PMID: 25124038
    3. introduction of the truncated human CCT epsilon subunit into yeast cells PMID: 22232265
    4. A missense mutation within the CCT5 gene is associated with autosomal recessive mutilating sensory neuropathy with spastic paraplegia. PMID: 16399879
  • 相关疾病：
    Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    TCP-1 chaperonin family
  • 数据库链接：

    HGNC: 1618

    OMIM: 256840

    KEGG: hsa:22948

    STRING: 9606.ENSP00000280326

    UniGene: Hs.1600