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  4. CBY1 Antibody

CBY1 Antibody

  • 货号：
    CSB-PA068175
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA068175(CBY1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA068175(CBY1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y3M2
  • 基因名：
    CBY1
  • 别名：
    ARPP-binding protein antibody; C22orf2 antibody; CBY antibody; Cby1 antibody; CBY1_HUMAN antibody; Cytosolic leucine rich protein antibody; Cytosolic leucine-rich protein antibody; Golgi and endoplasmic reticulum-associated 1 antibody; HRIHFB2025 antibody; PIGEA 14 antibody; PIGEA-14 antibody; PKD2 interactor antibody; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1 antibody; Protein Chibby antibody; Protein chibby homolog 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human CBY1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
  • 基因功能参考文献：
    1. FAM92 proteins interact with Cby1 to promote ciliogenesis via regulation of membrane-remodeling processes. PMID: 27528616
    2. chronic Cby1 knockdown in colon cancer cells may counteract tumor progression by promoting the mesenchymal-to-epithelial transition process. PMID: 28107095
    3. Cby's C-terminal domain alone binds to TC-1 with significantly greater affinity compared to full-length Cby, implying that target binding of the coiled-coil domain is affected by the flanking disordered regions. PMID: 27082063
    4. CBY1 downregulation in CML comes from reduced protein stability when bound to 14-3-3sigma adapter protein. Dissociation raises CBY1 protein levels by enhancing its stability. The ubiquitin proteasome system reduces 14-3-3sigma-bound CBY1 stability by SUMOylation. PMID: 26147002
    5. Study showed that expression of Cby protein was strongly downregulated in laryngeal squamous cell carcinoma (LSCC) tumor tissues in comparison to normal laryngeal mucosa samples. PMID: 25175341
    6. the impact of BCR-ABL1 on Chibby1, a beta catenin antagonist involved in cell differentiation and transformation PMID: 24339928
    7. Stable expression of CBY1 drives beta catenin cytoplasmatic translocation and impairs beta catenin signaling in BCR-ABL + cells. PMID: 23707389
    8. Results from the association analysis suggest that common variation in CBY is not a cause for obesity in the Belgian population. PMID: 23645032
    9. C-terminal polycystin-2 influences the interaction with PIGEA14 PMID: 23838289
    10. Cby plays an important role in organization of both primary and motile cilia in collaboration with Cnx. PMID: 22911743
    11. The N-terminal portion of the CBY1 is unstructured in solution, but the C-terminal half forms a coiled-coil structure. PMID: 21182262
    12. Chibby and clusterin were co-immunoprecipitated with NBPF1. PMID: 20096688
    13. These findings unravel the molecular basis through which a combinatorial action of Cby and 14-3-3 proteins controls the dynamic nuclear-cytoplasmic trafficking of beta-catenin. PMID: 19940019
    14. Chibby inhibits beta-catenin-mediated transcriptional activation by competing with Lef-1 to bind to beta-catenin PMID: 12712206
    15. PIGEA-14 plays an important role in regulating the intracellular location of polycystin-2 PMID: 15194699
    16. As no somatic mutation was detected in C22orf2 in 36 colorectal tumour DNA, our results do not support the implication of Chibby as a tumour suppressor in colorectal carcinogenesis. PMID: 15245581
    17. Chibby is not likely to promote colorectal carcinoma tumor development or progression. PMID: 16570344
    18. CBY promotes adipocyte differentiation through inhibition of beta catenin signaling. PMID: 17403895
    19. intrinsically disordered TC-1 interacts with Cby via its transient helical structure PMID: 17905836
    20. 14-3-3epsilon and 14-3-3zeta are identified as Cby-binding partners. PMID: 18573912
    21. genes including CHIBBY involved in pediatric ependymomas. PMID: 18663750
    22. Alanine substitutions of two or more of four critical leucine residues within the C-terminal heptad repeats eliminate the Cby-Cby interaction. PMID: 19435523

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  • 亚细胞定位：
    Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus. Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    Chibby family
  • 组织特异性：
    Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors.
  • 数据库链接：

    HGNC: 1307

    OMIM: 607757

    KEGG: hsa:25776

    STRING: 9606.ENSP00000216029

    UniGene: Hs.334911