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BLVRB Antibody

  • 货号：
    CSB-PA002722HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate, PC3 whole cell lysate, HepG2 whole cell lysate
      All lanes: BLVRB antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 23 kDa
      Observed band size: 23 kDa
    • IHC image of CSB-PA002722HA01HU diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA002722HA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BLVRB Polyclonal antibody
  • Uniprot No.：
    P30043
  • 基因名：
    BLVRB
  • 别名：
    Biliverdin IX beta reductase antibody; biliverdin reductase B (flavin reductase (NADPH)) antibody; Biliverdin reductase B antibody; Biliverdin-IX beta-reductase antibody; BLVRB antibody; BLVRB_HUMAN antibody; BVR B antibody; BVR-B antibody; BVRB antibody; epididymis secretory protein Li 10 antibody; Flavin reductase (NADPH) antibody; Flavin reductase antibody; FLR antibody; FR antibody; GHBP antibody; Green heme binding protein antibody; Green heme-binding protein antibody; HEL-S-10 antibody; Methemoglobin reductase antibody; MGC117413 antibody; NADPH dependent diaphorase antibody; NADPH flavin reductase antibody; NADPH-dependent diaphorase antibody; NADPH-flavin reductase antibody; SDR43U1 antibody; short chain dehydrogenase/reductase family 43U; member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Flavin reductase (NADPH) protein (2-206AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，BLVRB Antibody (CSB-PA002722HA01HU)，的标记方式是Non-conjugated。对于BLVRB Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA002722HB01HU BLVRB Antibody, HRP conjugated ELISA
    FITC CSB-PA002722HC01HU BLVRB Antibody, FITC conjugated
    Biotin CSB-PA002722HD01HU BLVRB Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
  • 基因功能参考文献：
    1. These results provide promising chemical scaffolds for the development of enhanced BLVRB inhibitors and identify chemical probes to better dissect the role of biliverdins, alternative substrates, and BLVRB function in physiologically relevant cellular contexts. PMID: 29487133
    2. These data define the first physiologically relevant function of BLVRB and implicate its activity and/or heme-regulated BV tetrapyrrole(s) in a unique redox-regulated bioenergetic pathway. PMID: 27207795
    3. miR-127-5p suppressed NF-kappaB activity by directly targeting BLVRB in hepatocellular carcinoma cells. PMID: 26708147
    4. quantum mechanics/molecular mechanics potential energy surfaces show that the lowest energy pathway proceeds with a positively charged pyrrole intermediate via two transition states PMID: 18241201
  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Predominantly expressed in liver and erythrocytes. At lower levels in heart, lung, adrenal gland and cerebrum.
  • 数据库链接：

    HGNC: 1063

    OMIM: 600941

    KEGG: hsa:645

    STRING: 9606.ENSP00000263368

    UniGene: Hs.515785