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BLVRB Antibody

  • 货号：
    CSB-PA002722GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P30043
  • 基因名：
    BLVRB
  • 别名：
    Biliverdin IX beta reductase antibody; biliverdin reductase B (flavin reductase (NADPH)) antibody; Biliverdin reductase B antibody; Biliverdin-IX beta-reductase antibody; BLVRB antibody; BLVRB_HUMAN antibody; BVR B antibody; BVR-B antibody; BVRB antibody; epididymis secretory protein Li 10 antibody; Flavin reductase (NADPH) antibody; Flavin reductase antibody; FLR antibody; FR antibody; GHBP antibody; Green heme binding protein antibody; Green heme-binding protein antibody; HEL-S-10 antibody; Methemoglobin reductase antibody; MGC117413 antibody; NADPH dependent diaphorase antibody; NADPH flavin reductase antibody; NADPH-dependent diaphorase antibody; NADPH-flavin reductase antibody; SDR43U1 antibody; short chain dehydrogenase/reductase family 43U; member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human BLVRB
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
  • 基因功能参考文献：
    1. These results provide promising chemical scaffolds for the development of enhanced BLVRB inhibitors and identify chemical probes to better dissect the role of biliverdins, alternative substrates, and BLVRB function in physiologically relevant cellular contexts. PMID: 29487133
    2. These data define the first physiologically relevant function of BLVRB and implicate its activity and/or heme-regulated BV tetrapyrrole(s) in a unique redox-regulated bioenergetic pathway. PMID: 27207795
    3. miR-127-5p suppressed NF-kappaB activity by directly targeting BLVRB in hepatocellular carcinoma cells. PMID: 26708147
    4. quantum mechanics/molecular mechanics potential energy surfaces show that the lowest energy pathway proceeds with a positively charged pyrrole intermediate via two transition states PMID: 18241201
  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Predominantly expressed in liver and erythrocytes. At lower levels in heart, lung, adrenal gland and cerebrum.
  • 数据库链接：

    HGNC: 1063

    OMIM: 600941

    KEGG: hsa:645

    STRING: 9606.ENSP00000263368

    UniGene: Hs.515785