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BDKRB1 Antibody

  • 货号：
    CSB-PA040277
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P46663
  • 基因名：
  • 别名：
    BDKRB1; BRADYB1; B1 bradykinin receptor; B1R; BK-1 receptor
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Bradykinin B1 R.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
  • 基因功能参考文献：
    1. The findings revealed that serum B1R levels may provide prognostic information and currently act as potential indicators for progression in atherosclerosis. PMID: 28990089
    2. Data show that mRNA and protein of bradykinin type 2 receptors, but not bradykinin type 1 receptors, were abundant in cultured c-Kit+ progenitor cells. PMID: 28099911
    3. promotes adhesion of neutrophils to endothelial cells PMID: 24728914
    4. kB1R heterodimerizes with kB2Rs in co-transfected HEK293 cells and natively expressing endothelial cells, resulting in significant internalization and desensitization of the kB1R response in cells pre-treated with kB2R agonist. PMID: 25289859
    5. BKR1 and BKR2 gene expression on peripheral monocytes is upregulated in essential hypertension PMID: 24401952
    6. B1 receptor-mediated vasodilatation in myometrial vessels absent in pre-eclampsia PMID: 24304135
    7. B1R agonist acts as a functional stimulus for the secretion of KLK1 and KLK6, an event relevant for kinin production and cell invasion, respectively PMID: 25503118
    8. Bradykinin B1 receptor signaling depends on receptor endocytosis. PMID: 23934212
    9. APJ and B1R can form heterodimers in transfected HEK293 cells and activations of APJ and B1R could up-regulate eNOS phosphorylation PMID: 24686079
    10. investigated if expression of B1 and B2 kinin receptors can be affected by IL-4 and IL-13; data show, for the first time, that IL-4 and IL-13 decrease kinin receptors in a STAT6-dependent mechanism PMID: 23351078
    11. A novel B1R splice variant and promoter regulatory elements determine tissue-specific B1R expression. PMID: 24475248
    12. the relevance of kinin B1 and B2 receptors in bladder cancer, was investigated. PMID: 23224295
    13. CPM binding to extracellular loop 2 of the B1R results in positive allosteric modulation of B1R signaling, and disruption of this interaction could provide a novel therapeutic approach to reduce pathological B1R signaling. PMID: 24108126
    14. This review focuses on airway MAPK/NFkappaB-dependent kinin receptor upregulation that links the environmental risk factors to airway hyperreactivity and airway inflammation. PMID: 23428345
    15. Kinin B1 receptor homo-oligomerization is required for receptor trafficking to the cell surface PMID: 23201435
    16. Bradykinin B1 receptor is induced in inflammatory diseases and contributes to hyperthermia through a vagal sensory mechanism. PMID: 22971439
    17. A peptidase-resistant BR agonist had no significant direct or indirect acute effect (4h) on BR expression. PMID: 21986309
    18. The transcriptional activity of the B1 receptor for kinins increased in patients with grade 1 and grade 2 endometrial cancer when compared to the control group, whereas it decreased in patients with grade 3 endometrial cancer. PMID: 22706224
    19. bradykinin B1 is inhibited by chromomenones PMID: 22088753
    20. The up-regulation of HER2 and B(1)R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis. PMID: 22468084
    21. Taken together, this study demonstrates that Pseudomonas aeruginosa is capable of up-regulating human B1R expression via the NF-kappaB signaling pathway. PMID: 22092568
    22. Comparing phospholipase C beta activity and Ca(2+)-regulated signals, a temperature-dependent increase was only observed for bradykinin B(1) but not for bradykinin(2)receptor activation. PMID: 21871009
    23. Remote ischemic preconditioning decreases expression of kinin receptors on circulating human neutrophils. PMID: 20189583
    24. CPM and B1Rs on cell membranes form a critical complex that potentiates B1R signaling. PMID: 21454694
    25. Data suggest that B1R inhibition can reduce BBB damage and cell invasion during autoimmune CNS disease and may offer a novel anti-inflammatory strategy for the treatment of MS. PMID: 21216565
    26. Release of metalloproteases-2 and -9 is blocked after silencing of the kinin B1 receptor with a siRNA. PMID: 21147512
    27. Severe inflammation characterizes rapidly progressive glomerulonephritides, and expression of the kinin B1 receptor (B1R) associates with inflammation. PMID: 20448019
    28. The up-regulation of B1 receptors may contribute to acute inflammatory pain through TRPV1 activation. PMID: 20152050
    29. human chondrosarcoma tissues had significantly higher expression of the B1 and B2 receptors comparing to normal cartilage PMID: 19885862
    30. Laminar shear stress is a major determinant of functional B1R expression in endothelium. PMID: 19661485
    31. B(1)R-epidermal growth factor receptor crosstalk may be a key interaction that maintains tumor growth PMID: 19184415
    32. both B1 receptor and gC1q receptor are involved in the vascular leakage induced by hereditary and acquired angioedema plasma. PMID: 19796797
    33. B1 and B2 receptor expression was enhanced in tumor cells and tissue adjacent to gastric cancer compared with gastric ulcers. PMID: 11710536
    34. Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor PMID: 11880373
    35. Bradykinin B1 receptors are upregulated by inflammatory stimuli in bronchial epithelial cells. PMID: 12063092
    36. the C-terminal domain participates intimately in the efficacy of B1R and B2R G(q/11) coupling by contributing both positive and negative regulatory epitopes. PMID: 12130679
    37. Allergic rhinitis subjects displayed significantly higher expression of B1 receptor mRNA than did the normal subjects. PMID: 12165532
    38. B1R exists in caveolae-related lipid rafts (CLRs) in HEK293 cells apparently by default, as a result of their random distribution in the plasma membrane and not by being targeted to the CLR fraction. PMID: 12450400
    39. B1 and B2 bradykinin receptors form a complex with enhanced signaling capacity PMID: 15033977
    40. Bradykinin B(1) receptor homooligomerization is required for expression of receptors on the cell surface and subsequent constitutive receptor signaling. PMID: 15492119
    41. kinin B(1) receptors participate in painful and inflammatory disorders--REVIEW PMID: 15520046
    42. slow internalization of B(1)KB(2) was also accompanied by a lack of agonist-induced phosphorylation, that in contrast was observed for B(1)YB(2) and B(1)CB(2), suggesting that putative helix 8 is either directly or indirectly involved PMID: 15634338
    43. the two bradykinin receptors may play a role in blood pressure regulation PMID: 15643125
    44. The B1 kinin receptor does not have a major vasomotor or fibrinolytic role in patients with heart failure PMID: 15681300
    45. Use of the highly sensitive DNase I in vivo footprinting approach to delineate more precisely the functional domains of the BDKRB1 gene promoter in human smooth muscle cells is reported. PMID: 15705059
    46. bradykinin receptors in imflammatory bowel disease may reflect intestinal inflammation PMID: 15805101
    47. A novel class of 2,3-diaminopyridine bradykinin B1 receptor antagonists is disclosed using structure-activity relationship studies. PMID: 15837330
    48. BK-1Rs are induced in the endothelium of intramyocardial coronary vessels in failing human hearts and so may participate in the pathogenesis of heart failure. PMID: 15840906
    49. Kinin B1 receptor expression on multiple sclerosis mononuclear cells PMID: 15883268
    50. Increased level of bradykinin receptor B1 in adenoma suggests that kinins may play a role in abnormal cellular transformation. PMID: 16644486

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Bradykinin receptor subfamily, BDKRB1 sub-subfamily
  • 数据库链接：

    HGNC: 1029

    OMIM: 600337

    KEGG: hsa:623

    STRING: 9606.ENSP00000216629

    UniGene: Hs.525572