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BCAM Antibody

  • 货号：
    CSB-PA341920LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA341920LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA341920LA01HU at dilution of 1:100
    • Immunofluorescence staining of HepG2 cells with CSB-PA341920LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BCAM Polyclonal antibody
  • Uniprot No.：
    P50895
  • 基因名：
    BCAM
  • 别名：
    Antigen identified by monoclonal antibody F8 antibody; AU antibody; Auberger B antigen antibody; B CAM cell surface glycoprotein antibody; B cell adhesion molecule antibody; B-CAM cell surface glycoprotein antibody; Basal cell adhesion molecule (Lu and Au blood groups) antibody; Basal cell adhesion molecule (Lutheran blood group) antibody; Basal cell adhesion molecule antibody; Basal cell adhesion molecule Lu and Au blood groups antibody; Basal cell adhesion molecule Lutheran blood group antibody; Bcam antibody; BCAM_HUMAN antibody; CD239 antibody; CD239 antigen antibody; F8/G253 antigen antibody; Glycoprotein 95kDa antibody; LU antibody; Lutheran antibody; Lutheran antigen antibody; Lutheran blood group (Auberger b antigen included) antibody; Lutheran blood group Auberger b antigen included antibody; Lutheran blood group glycoprotein antibody; MSK19 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Basal cell adhesion molecule protein (447-547AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，BCAM Antibody (CSB-PA341920LA01HU)，的标记方式是Non-conjugated。对于BCAM Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA341920LB01HU BCAM Antibody, HRP conjugated ELISA
    FITC CSB-PA341920LC01HU BCAM Antibody, FITC conjugated
    Biotin CSB-PA341920LD01HU BCAM Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Laminin alpha-5 receptor. May mediate intracellular signaling.
  • 基因功能参考文献：
    1. Lu expression by erythrocytes from patients with myeloproliferative neoplasms and splanchnic venous thrombosi is significantly increased compared to erythrocytes from healthy individuals PMID: 29756283
    2. This is the first report showing that Lu/BCAM, in the presence of its ligand laminin, is oncogenic in human urothelial cancers and may have potential as a novel therapeutic target. PMID: 28841878
    3. The serum levels of IL-8, MIP-1 alpha, MIP-1 beta, MMP-8, Resistin, FLRG, and BCAM were significantly higher in breast cancer patients, but LAP and TSH-beta levels were lower. PMID: 26898119
    4. four new alleles with coding sequence variants were identified in the LU gene PMID: 27043150
    5. Cytometry analysis evidenced a specific expression profile on reticulocytes of SCA infants, with notably an increased expression of the adhesion molecules Lu/BCAM, ICAM-4 and LFA-3, both in percentage of positive cells and in surface density. PMID: 26137540
    6. These studies revealed amino acids 720 to 1014 of CNF1 as the binding site for Lu/BCAM. PMID: 24453976
    7. High BCAM expression is associated with hepatocellular carcinoma. PMID: 25051049
    8. Adhesion of sickle reticulocytes to HC-treated endothelial cells was decreased despite the HC-derived increase of Lu/BCAM expression. PMID: 24616094
    9. tumor cell migration on LM-511 requires that Lu/B-CAM competitively modulates cell attachment through integrins. PMID: 24036115
    10. DARC and BCAM expression was associated with pathogenesis of thyroid carcinoma and correlated with clinical-pathological features. PMID: 23168236
    11. Glu425 in the Lu glycoprotein is required for expression of Lu7, and Ala425 is associated with the LU:-7 phenotype. This completes the molecular basis associated with all antigens known to be in the Lutheran blood group system. PMID: 23421542
    12. Increases in adhesion frequency provide significant evidence of the role of epinephrine in BCAM/Lu-laminin and ICAM-4-alpha(v)beta(3) bonding, and suggest mechanisms of vaso-occlusion during physical exertion in sickle cell trait. PMID: 22404936
    13. Aggregation of mononuclear and red blood cells through an {alpha}4{beta}1-Lu/basal cell adhesion molecule interaction in sickle cell disease PMID: 20562314
    14. BCAM glycoproteins are the unique erythroid receptors of laminin alpha5 chain, a major component of the extracellular matrix and are involved in several erythrocyte diseases. PMID: 20655789
    15. Results demonstrate that the alpha5 LG3 module is essential for the Lutheran blood group glycoprotein (Lu) binding to laminin alpha5. PMID: 12244066
    16. B-CAM/LU is the most critical receptor mediating adhesion to laminin under both static and flow conditions in sickle cell anemia. PMID: 14755370
    17. interactions of B-CAM and laminin may be involved in progression of epithelial skin tumors PMID: 15278364
    18. Lu mediates the adhesion of human endothelial cells to alpha5 laminins in collaboration with integrins beta(1) and alpha(v)beta(3). PMID: 16236823
    19. B-CAM spliceoform seems to be overexpressed by a variety of different malignant tumors and may be involved, along with other adhesion receptor proteins, in malignant transformation and tumor metastasis. (review) PMID: 16584446
    20. The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3. PMID: 17638854
    21. study presents a combined modeling & small angle X-ray scattering approach that extends the structural analysis of Lu gp to all five extracellular domains & provides further insight to its interaction with laminins (Ln511 & Ln521) PMID: 18302987
    22. Lu/BCAM gps expressed on erythroid or on endothelial cells are involved in SS RBC-endothelium interactions & could play a role in abnormal adhesion of SS RBCs to vascular endothelium contributing to vaso-occlusive crises reported for sickle cell disease. PMID: 18514010
    23. the interaction of the Lu cytoplasmic tail with the cytoskeleton regulates its adhesive receptor function PMID: 18815288
    24. CD239 was expressed in a constitutive fashion in polycythaemia vera-derived bone marrow cells and thus a pro-thrombotic function does not seem to be mediated by increased CD239 expression alone. PMID: 18972067
    25. Lutheran blood group glycoprotein (Lu) is one of the proteins cleaved by MT1-MMP. PMID: 19667067

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.
  • 数据库链接：

    HGNC: 6722

    OMIM: 111200

    KEGG: hsa:4059

    STRING: 9606.ENSP00000270233

    UniGene: Hs.625725