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  4. BCAM Antibody

BCAM Antibody

  • 货号：
    CSB-PA908140
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA908140(BCAM Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: NIH/3T3 cells, Primary antibody: CSB-PA908140(BCAM Antibody) at dilution 1/476, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    P50895
  • 基因名：
    BCAM
  • 别名：
    Antigen identified by monoclonal antibody F8 antibody; AU antibody; Auberger B antigen antibody; B CAM cell surface glycoprotein antibody; B cell adhesion molecule antibody; B-CAM cell surface glycoprotein antibody; Basal cell adhesion molecule (Lu and Au blood groups) antibody; Basal cell adhesion molecule (Lutheran blood group) antibody; Basal cell adhesion molecule antibody; Basal cell adhesion molecule Lu and Au blood groups antibody; Basal cell adhesion molecule Lutheran blood group antibody; Bcam antibody; BCAM_HUMAN antibody; CD239 antibody; CD239 antigen antibody; F8/G253 antigen antibody; Glycoprotein 95kDa antibody; LU antibody; Lutheran antibody; Lutheran antigen antibody; Lutheran blood group (Auberger b antigen included) antibody; Lutheran blood group Auberger b antigen included antibody; Lutheran blood group glycoprotein antibody; MSK19 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human BCAM
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Laminin alpha-5 receptor. May mediate intracellular signaling.
  • 基因功能参考文献：
    1. Lu expression by erythrocytes from patients with myeloproliferative neoplasms and splanchnic venous thrombosi is significantly increased compared to erythrocytes from healthy individuals PMID: 29756283
    2. This is the first report showing that Lu/BCAM, in the presence of its ligand laminin, is oncogenic in human urothelial cancers and may have potential as a novel therapeutic target. PMID: 28841878
    3. The serum levels of IL-8, MIP-1 alpha, MIP-1 beta, MMP-8, Resistin, FLRG, and BCAM were significantly higher in breast cancer patients, but LAP and TSH-beta levels were lower. PMID: 26898119
    4. four new alleles with coding sequence variants were identified in the LU gene PMID: 27043150
    5. Cytometry analysis evidenced a specific expression profile on reticulocytes of SCA infants, with notably an increased expression of the adhesion molecules Lu/BCAM, ICAM-4 and LFA-3, both in percentage of positive cells and in surface density. PMID: 26137540
    6. These studies revealed amino acids 720 to 1014 of CNF1 as the binding site for Lu/BCAM. PMID: 24453976
    7. High BCAM expression is associated with hepatocellular carcinoma. PMID: 25051049
    8. Adhesion of sickle reticulocytes to HC-treated endothelial cells was decreased despite the HC-derived increase of Lu/BCAM expression. PMID: 24616094
    9. tumor cell migration on LM-511 requires that Lu/B-CAM competitively modulates cell attachment through integrins. PMID: 24036115
    10. DARC and BCAM expression was associated with pathogenesis of thyroid carcinoma and correlated with clinical-pathological features. PMID: 23168236
    11. Glu425 in the Lu glycoprotein is required for expression of Lu7, and Ala425 is associated with the LU:-7 phenotype. This completes the molecular basis associated with all antigens known to be in the Lutheran blood group system. PMID: 23421542
    12. Increases in adhesion frequency provide significant evidence of the role of epinephrine in BCAM/Lu-laminin and ICAM-4-alpha(v)beta(3) bonding, and suggest mechanisms of vaso-occlusion during physical exertion in sickle cell trait. PMID: 22404936
    13. Aggregation of mononuclear and red blood cells through an {alpha}4{beta}1-Lu/basal cell adhesion molecule interaction in sickle cell disease PMID: 20562314
    14. BCAM glycoproteins are the unique erythroid receptors of laminin alpha5 chain, a major component of the extracellular matrix and are involved in several erythrocyte diseases. PMID: 20655789
    15. Results demonstrate that the alpha5 LG3 module is essential for the Lutheran blood group glycoprotein (Lu) binding to laminin alpha5. PMID: 12244066
    16. B-CAM/LU is the most critical receptor mediating adhesion to laminin under both static and flow conditions in sickle cell anemia. PMID: 14755370
    17. interactions of B-CAM and laminin may be involved in progression of epithelial skin tumors PMID: 15278364
    18. Lu mediates the adhesion of human endothelial cells to alpha5 laminins in collaboration with integrins beta(1) and alpha(v)beta(3). PMID: 16236823
    19. B-CAM spliceoform seems to be overexpressed by a variety of different malignant tumors and may be involved, along with other adhesion receptor proteins, in malignant transformation and tumor metastasis. (review) PMID: 16584446
    20. The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3. PMID: 17638854
    21. study presents a combined modeling & small angle X-ray scattering approach that extends the structural analysis of Lu gp to all five extracellular domains & provides further insight to its interaction with laminins (Ln511 & Ln521) PMID: 18302987
    22. Lu/BCAM gps expressed on erythroid or on endothelial cells are involved in SS RBC-endothelium interactions & could play a role in abnormal adhesion of SS RBCs to vascular endothelium contributing to vaso-occlusive crises reported for sickle cell disease. PMID: 18514010
    23. the interaction of the Lu cytoplasmic tail with the cytoskeleton regulates its adhesive receptor function PMID: 18815288
    24. CD239 was expressed in a constitutive fashion in polycythaemia vera-derived bone marrow cells and thus a pro-thrombotic function does not seem to be mediated by increased CD239 expression alone. PMID: 18972067
    25. Lutheran blood group glycoprotein (Lu) is one of the proteins cleaved by MT1-MMP. PMID: 19667067

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.
  • 数据库链接：

    HGNC: 6722

    OMIM: 111200

    KEGG: hsa:4059

    STRING: 9606.ENSP00000270233

    UniGene: Hs.625725