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ARMCX1 Antibody

  • 货号：
    CSB-PA000929
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of mouse-brain cells using ARMCX1 Polyclonal Antibody
    • Western Blot analysis of MOUSE-BRAIN cells using ARMCX1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9P291
  • 基因名：
    ARMCX1
  • 别名：
    ARMCX 1 antibody; AD032 antibody; ALEX1 antibody; ARM protein lost in epithelial cancers on chromosome X 1 antibody; Arm protein lost in epithelial cancers X chromosome 1 antibody; Armadillo repeat containing X linked 1 antibody; Armadillo repeat containing X linked protein 1 antibody; Armadillo repeat-containing X-linked protein 1 antibody; ARMCX1 antibody; ARMX1_HUMAN antibody; Protein ALEX1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human ARMCX1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1.
  • 基因功能参考文献：
    1. It is suggested that the ALEX1 protein is associated with tumorigenesis in cervical cancer and we speculate that the ALEX1 may plays a role as an oncogene in cervical cancer. PMID: 26464700
    2. ALEX1 is a crucial tumor suppressor gene involved in cell proliferation and apoptosis in breast cancer. PMID: 25921134
    3. Findings suggest that overexpression of ALEX1 (armadillo repeat containing, X-linked [ARMCX]) plays a negative role in colorectal tumorigenesis. PMID: 22494058
    4. Human Arm protein lost in epithelial cancers, on chromosome X 1 (ALEX1) gene is transcriptionally regulated by CREB and Wnt/beta-catenin signaling. PMID: 20398052
  • 亚细胞定位：
    Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein.
  • 蛋白家族：
    Eutherian X-chromosome-specific Armcx family
  • 组织特异性：
    Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not or reduced expressed in lung, prostate, colon, pancreas and ovarian carci
  • 数据库链接：

    HGNC: 18073

    OMIM: 300362

    KEGG: hsa:51309

    STRING: 9606.ENSP00000361917

    UniGene: Hs.9728