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APEH Antibody

  • 货号：
    CSB-PA001899LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA001899LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA001899LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA001899LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: Hela whole cell lysate
      All lanes: APEH antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 82 kDa
      Observed band size: 82 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA001899LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) APEH Polyclonal antibody
  • Uniprot No.：
    P13798
  • 基因名：
    APEH
  • 别名：
    AARE antibody; ACPH antibody; ACPH_HUMAN antibody; Acyl peptide hydrolase antibody; Acyl-peptide hydrolase antibody; Acylamino acid releasing enzyme antibody; Acylamino-acid-releasing enzyme antibody; Acylaminoacyl peptidase antibody; Acylaminoacyl-peptidase antibody; APEH antibody; APH antibody; N acylaminoacyl peptide hydrolase antibody; OPH antibody; Oxidized protein hydrolase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Acylamino-acid-releasing enzyme protein (201-500AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，APEH Antibody (CSB-PA001899LA01HU)，的标记方式是Non-conjugated。对于APEH Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA001899LB01HU APEH Antibody, HRP conjugated ELISA
    FITC CSB-PA001899LC01HU APEH Antibody, FITC conjugated
    Biotin CSB-PA001899LD01HU APEH Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:2000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.
  • 基因功能参考文献：
    1. Although APEH is primarily localized in the cytoplasm, a sub-fraction of this enzyme is sequestered at sites of nuclear damage following UVA irradiation or following oxidative stress. APEH interacts with the amino-terminal domain of XRCC1, and APEH facilitates both single-strand break repair and cell survival following exposure to H2O2. Thus, APEH as a novel proteolytic component of the DNA damage response. PMID: 28866241
    2. APEH polymorphism has significant influence on valproic acid pharmacokinetics in Chinese population PMID: 27406852
    3. Studies indicate that the cylindromatosis/turban tumor syndrome gene (CYLD) ranked highest, followed by acylaminoacyl-peptidase (APEH), dystroglycan (DAG1), macrophage-stimulating protein (MST1) and ubiquitin-specific peptidase 4 (USP4). PMID: 21931648
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase S9C family
  • 数据库链接：

    HGNC: 586

    OMIM: 102645

    KEGG: hsa:327

    STRING: 9606.ENSP00000296456

    UniGene: Hs.517969