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ANGPTL7 Antibody

  • 货号：
    CSB-PA001715LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ANGPTL7 antibody at 2µg/ml
      Lane 1: MCF-7 whole cell lysate
      Lane 2: Colo320 whole cell lysate
      Lane 3: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 41 kDa
      Observed band size: 41 kDa
    • Immunohistochemistry of paraffin-embedded human salivary gland tissue using CSB-PA001715LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA001715LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    The ANGPTL7 antibody is a polyclonal antibody generated in rabbits by immunization with recombinant human ANGPTL7 protein consisting of amino acids 27-296. This antibody is capable of detecting ANGPTL7 in human samples, indicating its specificity for this target protein. The ANGPTL7 antibody has been purified using Protein G, resulting in a purity of greater than 95%.

    The ANGPTL7 polyclonal antibody is a valuable tool for researchers interested in studying the role of ANGPTL7 in human physiology and disease. It has validated validity in ELISA, WB, and IHC applications, increasing its versatility in experimental settings.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ANGPTL7 Polyclonal antibody
  • Uniprot No.：
    O43827
  • 基因名：
    ANGPTL7
  • 别名：
    Angiopoietin like 7 antibody; Angiopoietin like factor (CDT6) antibody; Angiopoietin like factor antibody; Angiopoietin related protein 7 antibody; Angiopoietin-like factor antibody; Angiopoietin-like protein 7 antibody; Angiopoietin-related protein 7 antibody; ANGL7_HUMAN antibody; ANGPTL7 antibody; AngX antibody; CDT6 antibody; Cornea derived transcript 6 protein antibody; Cornea-derived transcript 6 protein antibody; dJ647M16.1 antibody; OTTHUMP00000001986 antibody; RP4-647M16.2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Angiopoietin-related protein 7 protein (27-296AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ANGPTL7 Antibody (CSB-PA001715LA01HU)，的标记方式是Non-conjugated。对于ANGPTL7 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA001715LB01HU ANGPTL7 Antibody, HRP conjugated ELISA
    FITC CSB-PA001715LC01HU ANGPTL7 Antibody, FITC conjugated
    Biotin CSB-PA001715LD01HU ANGPTL7 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure. Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency.
  • 基因功能参考文献：
    1. obesity increases the level of ANGPTL7 in both plasma and adipose tissue. Increased expression of ANGPTL7 might play a minor role in the regulation of TG level in obese subjects either directly or through interaction with other ANGPTL protein members. Physical exercise reduced the level of ANGPTL7 highlighting the potential for targeting this protein as a therapeutic target for regulating dyslipidemia. PMID: 28264047
    2. ANGPTL7, which is abundantly expressed in keratocytes, plays a major role in maintaining corneal avascularity and transparency. PMID: 25622036
    3. ANGPTL7 is markedly down regulated in metastatic liver cancer. PMID: 25854806
    4. Angiopoietin-like 7 is a novel pro-angiogenetic factor over-expressed in cancer PMID: 24903490
    5. Together with previous findings, these properties strengthen ANGPTL7's candidacy for the regulation of intraocular pressure and glaucoma. PMID: 21199193
    6. Induction of ANGPTL7 secretion by glaucoma stimuli and increased concentration of ANGPTL7 in glaucomatous AH suggest that ANGPTL7 is overexpressed in glaucoma. PMID: 18421092

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Higly expressed in the cornea (at protein level). Expression is restricted to the stromal layer. Also detected at the junction between the corneal stromal layer and the conjuctiva. Not detected in the sclera.
  • 数据库链接：

    HGNC: 24078

    KEGG: hsa:10218

    STRING: 9606.ENSP00000366015

    UniGene: Hs.146559