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AGPS Antibody

  • 货号：
    CSB-PA001457LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate
      All lanes: AGPS antibody at 2.7µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 73 kDa
      Observed band size: 73 kDa
    • IHC image of CSB-PA001457LA01HU diluted at 1:500 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of NIH/3T3 cells with CSB-PA001457LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AGPS Polyclonal antibody
  • Uniprot No.：
    O00116
  • 基因名：
  • 别名：
    AAG5 antibody; ADAP-S antibody; ADAS antibody; ADAS_HUMAN antibody; ADHAPS antibody; ADPS antibody; Aging associated gene 5 protein antibody; Aging-associated gene 5 protein antibody; aging-associated protein 5 antibody; AGPS antibody; ALDHPSY antibody; Alkyl-DHAP synthase antibody; Alkyldihydroxyacetonephosphate synthase antibody; Alkyldihydroxyacetonephosphate synthase, peroxisomal antibody; Alkylglycerone phosphate synthase antibody; Alkylglycerone-phosphate synthase antibody; peroxisomal antibody; RCDP3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Alkyldihydroxyacetonephosphate synthase, peroxisomal protein (279-400AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，AGPS Antibody (CSB-PA001457LA01HU)，的标记方式是Non-conjugated。对于AGPS Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA001457LB01HU AGPS Antibody, HRP conjugated ELISA
    FITC CSB-PA001457LC01HU AGPS Antibody, FITC conjugated
    Biotin CSB-PA001457LD01HU AGPS Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis.
  • 基因功能参考文献：
    1. we optimized the BITC construction targeting alkylglycerone phosphate synthase (AGPS) by computer-aided design, and the derivants also showed anti-tumor potential in vitro. PMID: 25542233
    2. AGPS overexpression could be a causation of chemotherapy agent resistance of cancer cells. AGPS silencing could lead to drug uptake and cell cycle arrest and apoptotic cell death. PMID: 24815474
    3. Results demonstrated that AGPS negatively regulated the invasion potential of glioma and hepatic carcinoma cells by modulating the expression of relevant genes and activity of the MAPK pathway. PMID: 24841318
    4. AGPS, in addition to maintaining ether lipids, also controls cellular utilization of fatty acids, favoring the generation of signaling lipids necessary for promoting the aggressive features of cancer. PMID: 23980144
    5. Novel mutations in AGPS (alkylglycerone-phosphate synthase) cause rhizomelic chondrodysplasia punctata (RCDP) type 3. PMID: 21990100
    6. Defect of ADAPS expression was also assessed by immunoblot PMID: 18571506

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  • 相关疾病：
    Rhizomelic chondrodysplasia punctata 3 (RCDP3)
  • 亚细胞定位：
    Peroxisome membrane. Peroxisome.
  • 蛋白家族：
    FAD-binding oxidoreductase/transferase type 4 family
  • 数据库链接：

    HGNC: 327

    OMIM: 600121

    KEGG: hsa:8540

    STRING: 9606.ENSP00000264167

    UniGene: Hs.516543