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AGPS Antibody

  • 货号：
    CSB-PA043528
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA043528(AGPS Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA043528(AGPS Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 231 and 293T cell, Primary antibody: CSB-PA043528(AGPS Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他：

产品详情

  • Uniprot No.：
    O00116
  • 基因名：
  • 别名：
    AAG5 antibody; ADAP-S antibody; ADAS antibody; ADAS_HUMAN antibody; ADHAPS antibody; ADPS antibody; Aging associated gene 5 protein antibody; Aging-associated gene 5 protein antibody; aging-associated protein 5 antibody; AGPS antibody; ALDHPSY antibody; Alkyl-DHAP synthase antibody; Alkyldihydroxyacetonephosphate synthase antibody; Alkyldihydroxyacetonephosphate synthase, peroxisomal antibody; Alkylglycerone phosphate synthase antibody; Alkylglycerone-phosphate synthase antibody; peroxisomal antibody; RCDP3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human AGPS
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis.
  • 基因功能参考文献：
    1. we optimized the BITC construction targeting alkylglycerone phosphate synthase (AGPS) by computer-aided design, and the derivants also showed anti-tumor potential in vitro. PMID: 25542233
    2. AGPS overexpression could be a causation of chemotherapy agent resistance of cancer cells. AGPS silencing could lead to drug uptake and cell cycle arrest and apoptotic cell death. PMID: 24815474
    3. Results demonstrated that AGPS negatively regulated the invasion potential of glioma and hepatic carcinoma cells by modulating the expression of relevant genes and activity of the MAPK pathway. PMID: 24841318
    4. AGPS, in addition to maintaining ether lipids, also controls cellular utilization of fatty acids, favoring the generation of signaling lipids necessary for promoting the aggressive features of cancer. PMID: 23980144
    5. Novel mutations in AGPS (alkylglycerone-phosphate synthase) cause rhizomelic chondrodysplasia punctata (RCDP) type 3. PMID: 21990100
    6. Defect of ADAPS expression was also assessed by immunoblot PMID: 18571506

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  • 相关疾病：
    Rhizomelic chondrodysplasia punctata 3 (RCDP3)
  • 亚细胞定位：
    Peroxisome membrane. Peroxisome.
  • 蛋白家族：
    FAD-binding oxidoreductase/transferase type 4 family
  • 数据库链接：

    HGNC: 327

    OMIM: 600121

    KEGG: hsa:8540

    STRING: 9606.ENSP00000264167

    UniGene: Hs.516543