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ADAMDEC1 Antibody

  • 货号：
    CSB-PA008874
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O15204
  • 基因名：
    ADAMDEC1
  • 别名：
    A disintegrin and metalloproteinase domain like protein decysin 1 antibody; A disintegrin and metalloproteinase domain-like protein decysin-1 antibody; ADAM DEC1 antibody; ADAM like decysin 1 antibody; ADAM like protein decysin 1 antibody; ADAM-like protein decysin-1 antibody; ADAMDEC 1 antibody; Adamdec1 antibody; ADEC1_HUMAN antibody; Decysin antibody; Disintegrin protease antibody; M12.219 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ADAMDEC1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play an important role in the control of the immune response and during pregnancy.
  • 基因功能参考文献：
    1. Data suggest that activated platelets release ADAMDEC1, which hydrolyzes pro-EGF (epidermal growth factor) to soluble, active HMW-EGF; proteolytic cleavage of pro-EGF first occurs at the C-terminal arginyl residue of the EGF domain; proteolysis is the regulated, rate-limiting step in generating soluble EGF from activated platelets. PMID: 28455445
    2. We hypothesize that these unique features of ADAMDEC1 may have evolved to escape from inhibition by endogenous metalloprotease inhibitors PMID: 25564618
    3. ADAMDEC1 functions as an active metalloprotease. PMID: 23754285
    4. molecular evolution by duplication in a metalloprotease gene cluster on chromosome 8p12 PMID: 12037602
    5. The ADAMDEC 1 haplotype may indicate an underlying mechanism for high FVIII levels in venous thromboembolism. PMID: 18449420
    6. Gene expression profiling performed on tissues obtained from pulmonary sarcoidosis patients identified ADAMDEC1 as a potential pathogenic mediator of lung damage and/or remodeling and may serve as a marker for this disease. PMID: 19218196

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in mon
  • 数据库链接：

    HGNC: 16299

    OMIM: 606393

    KEGG: hsa:27299

    STRING: 9606.ENSP00000256412

    UniGene: Hs.521459