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  4. Recombinant Mouse Uteroglobin protein (Scgb1a1)

Recombinant Mouse Uteroglobin protein (Scgb1a1)

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  • 货号：
    CSB-AP000561MO
  • 规格：
    ￥852
  • 图片：
  • 其他：

产品详情

  • 纯度：
    >98% as determined by SDS-PAGE.
  • 内毒素：
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性：
    Fully biologically active when compared to standard. The ED50 as determined by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells is less than 5.0 μg/ml, corresponding to a specific activity of >200 IU/m.
  • 基因名：
    Scgb1a1
  • Uniprot No.：
  • 别名：
    Scgb1a1; Cc10; Ugb; Utg; Uteroglobin; Clara cell 17 kDa protein; Clara cell phospholipid-binding protein; CCPBP; Clara cells 10 kDa secretory protein; CC10; PCB-binding protein; Secretoglobin family 1A member 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.Coli
  • 分子量：
    8.4 kDa
  • 表达区域：
    22-96aa
  • 氨基酸序列
    DICPGFLQVL EALLMESESG YVASLKPFNP GSDLQNAGTQ LKRLVDTLPQ ETRINIMKLT EKILTSPLCK QDLRF
  • 蛋白标签：
    Tag-Free
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    0.2 μm filtered 20 mM PB, pH 7.4, 150mM NaCl ,lyophilized
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    5-10 business days
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
  • 基因功能参考文献：
    1. the present results demonstrate that rCC16 has therapeutic effects on COPD by downregulating proinflammatory factors via the NFkappaB pathway. PMID: 29956762
    2. This study extends the function of the Scgb1a1-expressing epithelial cell population as a major mediator of the antiviral response. It PMID: 29593031
    3. Chronic P. aeruginosa inflammation resulted in chronic bronchitis and emphysematous changes in CCSP-deficient mice. PMID: 27703342
    4. CC16 protects lungs from cigarette smoke (CS)-induced injury by reducing lung NF-kappaB activation. CS-induced airway CC16 deficiency increases CS-induced pulmonary inflammation and injury and likely contributes to the pathogenesis of COPD. PMID: 25700379
    5. Depletion of bone marrow CCSP-expressing cells delays airway regeneration. PMID: 25409745
    6. Serum CC-16 is associated with disease progression in chronic obstructive pulmonary disease (COPD). However, the absence of CC-16 does not appear to modify the risk of cigarette-related COPD in mice. PMID: 24245748
    7. These findings indicate that CCSP has a regulatory role in obliterative bronchiolitis. PMID: 23997179
    8. the role of clara cells and clara cell secretory protein in lung radiation injury exacerbated by viral infection PMID: 23621375
    9. AAV2/9-CC10 vector virus guaranteed sufficient CC10 expression and had an anti-inflammatory effect in asthmatic mice. PMID: 23013277
    10. Claudin-3 and Clara cell 10 kDa protein were identified as possible markers of early tobacco smoke-induced epithelial injury along alveolar ducts. PMID: 22659244
    11. Scgb1a1-expressing cells, most likely Clara cells, are a major cell type that gives rise to alveolar type I and II cells during the regeneration of alveolar epithelia in response to severe pulmonary damage in mice. PMID: 23119022
    12. These results indicate that CC10 gene transfer may inhibit airway inflammation through suppressing the activation of NF-kappaB. PMID: 22558282
    13. Clara cell secretory protein expression is elevtaed in lungs after long-term n-hexane inhalation exposure. PMID: 20853679
    14. CCSP promoter has a role in alveolar development PMID: 20693404
    15. The expression of CC10 is downregulated in sinonasal mucosa in bacterial chronic rhinosinusitis. PMID: 19119605
    16. Expression of SCGB1A1 mRNA was not decreased in vivo in the absence of C/EBPs. PMID: 21224212
    17. The differential expression of mRNA by both airway level and lung region was determined for Clara cell secretory protein. PMID: 20852037
    18. Lack of uteroglobin in mice enhances colonization of B16F10 melanoma cells in the lungs. PMID: 20118237
    19. macrophages from Clara cell-depleted and CCSP(-/-) mice displayed increased Toll-like receptor 4 surface expression PMID: 19423773
    20. Uteroglobin promoter-targeted c-MYC expression in transgenic mice cause hyperplasia of Clara cells and malignant transformation of T-lymphoblasts and tubular epithelial cells PMID: 11817538
    21. Data show that Clara cell secretory protein (CCSP) is required for the appearance of secretory granules and that functional changes to Clara cells that result from CCSP deficiency lead to alterations in the composition of epithelial lining fluid. PMID: 12151308
    22. demonstrate synergistic transactivation by C/EBPalpha and Nkx2.1 in the regulation of the CCSP gene PMID: 12161423
    23. An immunohistochemical analysis was made of the expression of this protein in a transgenic model of mouse lung carcinogenesis. PMID: 12699910
    24. Restoration of CCSP in the airways of CCSP-deficient mice abrogates the increase in viral persistence, lung inflammation, and airway hyperreactivity induced by respiratory syncytial virus infection. PMID: 12847279
    25. Multiple mechanisms for repression of the Clara cell secretory protein gene during hyperoxia. PMID: 14500549
    26. Data show that 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone exposure of Clara cell 10-kDa protein knock-out mice causes a significantly higher incidence of airway epithelial hyperplasia and lung adenomas compared with wild type littermates. PMID: 15148323
    27. plays a direct role in the regulation of T-cell-mediated inflammatory responses. PMID: 15356574
    28. We propose that mechanical activation of the cPLA2 pathway contributes to acute high PIP-induced lung injury and that CCSP may reduce this injury through inhibition of the cPLA2 pathway and reduction of proinflammatory products produced by this pathway. PMID: 15608088
    29. Uteroglobin suppresses SCCA gene expression associated with airway inflammation in asthma PMID: 15677460
    30. uteroglobin plays important roles in maintaining homeostasis in organs that are vulnerable to inadvertent stimulation of FP-mediated inflammatory response by inhibiting the prostaglandin F2alpha receptor PMID: 16061484
    31. A critical role for uteroglobin in preventing the development of pulmonary fibrosis. PMID: 16872605
    32. These results suggest that both long- and short-range paracrine signaling between nonciliated secretory cells and cells of the immune system and epithelium impact modification of cell type-specific proteins. PMID: 17384087
    33. Treatment of lung neoplasms with bexarotene resulted in decreased mRNA expression. PMID: 17849452
    34. Clara cells accumulated Clara cell secretory protein (CCSP) in Munc13-2-deficient mice. PMID: 18258655
    35. preferentially expressed in mouse model of allergen-induced airway inflammation and remodeling PMID: 19322781

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Secretoglobin family
  • 组织特异性：
    Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).
  • 数据库链接：

    KEGG: mmu:22287

    STRING: 10090.ENSMUSP00000025554

    UniGene: Mm.2258