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HAO1 Monoclonal Antibody

  • 货号：
    CSB-MA080172
  • 规格：
    ￥660
  • 图片：
    • Western blot analysis of 1) Mouse Liver Tissue, 2) Rat Liver Tissue using HAO1 Monoclonal Antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q9UJM8
  • 基因名：
    HAO1
  • 别名：
    (S) 2 hydroxy acid oxidase antibody; Glycolate oxidase antibody; GOX antibody; GOX1 antibody; HAO1 antibody; HAOX1 antibody; HAOX1_HUMAN antibody; Hydroxyacid oxidase 1 antibody; MGC142225 antibody; MGC142227 antibody; OTTHUMP00000030231 antibody
  • 宿主：
    Mouse
  • 反应种属：
    Mouse,Rat
  • 免疫原：
    Recombinant Protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
  • 基因功能参考文献：
    1. The study presents the first spectroscopic evidence of the formation of an intermediate with absorbance features resembling those of a flavosemiquinone in the oxidative half-reaction of glycolate oxidase. PMID: 21141873
    2. The inhibitor heteroatoms interact with five active-site residues that have been implicated in catalysis in homologous flavodehydrogenases of L-2-hydroxy acids. In addition, the chlorophenyl substituent is surrounded by nonconserved hydrophobic residues. PMID: 20054120
    3. These inhibitions suggest that glycolate binds to the active site of the reduced enzyme, and that DCIP also has affinity for the oxidized enzyme. PMID: 17669354
    4. Active site and loop 4 movements within human glycolate oxidase. PMID: 18215067
  • 亚细胞定位：
    Peroxisome.
  • 蛋白家族：
    FMN-dependent alpha-hydroxy acid dehydrogenase family
  • 组织特异性：
    Liver.
  • 数据库链接：

    HGNC: 4809

    OMIM: 605023

    KEGG: hsa:54363

    STRING: 9606.ENSP00000368066

    UniGene: Hs.193640