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  4. Recombinant Human Interleukin-11 protein (IL11)

Recombinant Human Interleukin-11 protein (IL11)

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  • 货号：
    CSB-AP001801HU
  • 规格：
    ￥2124
  • 图片：
  • 其他：

产品详情

  • 纯度：
    >95% as determined by SDS-PAGE.
  • 内毒素：
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性：
    Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine B9-11 cells is less than 1 ng/ml, corresponding to a specific activity of >1.0x106 IU/mg.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Adipogenesis inhibitory factor; AGIF; IL 11; IL-11; Il11; IL11_HUMAN; Interleukin 11; Interleukin-11; Oprelvekin
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.Coli
  • 分子量：
    19.1 kDa
  • 表达区域：
    22-199aa
  • 氨基酸序列
    M+PGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL
  • 蛋白标签：
    Tag-Free
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    0.2 μm filtered PBS, pH 7.4 ,lyophilized
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    5-10 business days
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'.
  • 基因功能参考文献：
    1. the identification of a dysregulated miR-124/IL-11 axis helps elucidate mechanisms of breast cancer metastases to bone, uncovers new prognostic markers, and facilitates the development of novel therapeutic targets to treat and even prevent bone metastases of breast cancer. PMID: 29343249
    2. The results indicate that miR-23b regulates IL-11 and IL-11Ralpha expression, and it might act as an anti-oncogenic agent in the progression of Hepatocellular Carcinoma by directly downregulating IL-11 expression. PMID: 29901200
    3. It has been concluded that the renal cell carcinoma risk allele at 12p12.1 maps to rs7132434, a functional variant in an enhancer that upregulates BHLHE41 expression which, in turn, induces IL-11, a member of the IL-6 cytokine family. PMID: 27384883
    4. The results indicated that miR-124a has an important role as a tumor suppressor gene by targeting IL-11. PMID: 29286137
    5. Studied the role of ZEB1-AS1, and it's association with IL-11, in promoting STAT3 activation in B-lymphoblastic leukemia. PMID: 28861713
    6. Cancer-associated fibroblasts treated with cisplatin facilitate chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway. PMID: 27922075
    7. results reveal a central role of IL-11 in fibrosis and we propose that inhibition of IL-11 is a potential therapeutic strategy to treat fibrotic diseases PMID: 29160304
    8. up-regulates GRP78 in the placenta PMID: 28487027
    9. The identification of the miR-206/TWF1/MKL1-SRF/IL11 signaling pathway sheds lights on the understanding of breast cancer initiation and progression, unveils new therapeutic targets, and facilitates innovative drug development to control cancer and block metastasis PMID: 27435395
    10. This review will discuss the available structural, functional, and bioinformatics knowledge concerning IL-11 and will summarize its relationship with several diseases PMID: 27312790
    11. s found a significant correlation between NRF2 and IL-11 status in breast cancer patients. Based on a recent report demonstrating that IL-11 is induced downstream of NRF2, s examined the significance of IL-11 in NRF2-driven tumorigenesis with a newly established NRF2 addiction cancer model. PMID: 28714957
    12. this study shows that recombinant IL-11 is effective with tolerable adverse effects in Chinese patients with autoimmune thrombocytopenic purpura PMID: 27235596
    13. HMGA2 promoted colorectal cancer metastasis and epithelial-mesenchymal transition via activation of the FN1 and IL11/STAT3 signaling pathways. PMID: 26964871
    14. Together, these results suggest that the IL-11/STAT3 signaling pathway plays a critical role in human chronic atrophic gastritis , and may provide new targets to prevent and treat gastric cancer PMID: 27173233
    15. Proteolysis of the IL-11R represents a molecular switch that controls the IL-11 trans-signaling pathway which is the target in intestinal tumorigenesis, lung carcinomas, and asthma. PMID: 26876177
    16. IL-11 has a protective role and can accelerate recovery of platelets, and remarkably lessen the extent of inflammatory responses, hence reducing the mortality in sepsis patients accompanied with thrombocytopenia. PMID: 26276375
    17. Results indicate that iterleukin-11 (IL11) is causal of Preeclampsia (PE) features in a mouse model and likely in women, and suggest potential of IL11 inhibition to rescue PE symptoms in women. PMID: 26655736
    18. The cross-talk between Th17 and interleukin 11 (IL-11+)CD4+ T cells may induce and amplify the autoimmune response in the early stage of multiple sclerosis (MS), and thus represent an attractive therapeutic target in this and other inflammatory diseases. PMID: 26452137
    19. Genetic variations of IL-11 may be associated with the risk of Hirschsprung disease and/or the mechanisms related to enteric nervous system development. PMID: 26172388
    20. IL-11 expression in breast cancer correlates with poor disease outcome PMID: 26209885
    21. data offer insight into the binding interactions of IL-11 with each of its receptors and the structural mechanisms underlying agonist and antagonist variants of the protein PMID: 25195742
    22. The highly specific IL-11 - S100P interaction occurring under physiologically relevant conditions should be taken into consideration upon development of the antineoplastics inhibiting IL-11 signaling. PMID: 26551460
    23. MTA2 overexpression enhances colony formation and tumor growth of gastric cancer cells, but not plays important role in cancer cell migration and metastasis. IL-11 is one of the downstream effectors of MTA2 in regulating gastric cancer cells growth PMID: 25929737
    24. IL-11 stimulates BSP gene transcription. PMID: 24633490
    25. The results prove the presence of the potentially functionally relevant IL-11 gene variants in the population of infertile women. PMID: 24635366
    26. High expression of interleukin-11 correlated with poor prognosis in clear-cell renal cell carcinoma patients. PMID: 25702890
    27. IL-11 is identified as a new Th17-promoting cytokine, because it induces a differentiation of naive CD4(+) T cells into Th17 cells, as well as expansion of Th17 memory cells. PMID: 25895532
    28. Low serum interleukin-11 are associated with pancreatic cancer. PMID: 25123265
    29. Pretreatment with rhIL-11 can reduce galactosamine-induced acute liver failure and protect the liver. PMID: 24817287
    30. In the presence of 100 ng/ml IL-11, GATA-3 transcript abundance rose up to ~85-fold of that measured in untreated cells, whereas T-bet transcripts were lowered merely to ~41% PMID: 24338248
    31. It Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. PMID: 23631681
    32. DNA methylation of the CpG island in the IL-11 gene is associated with response of major depressive disorder patients to antidepressant drugs. PMID: 24002086
    33. IL-11 is associated with bone metastasis. PMID: 23813018
    34. IL11 given orally protects the intestinal mucosa from radiation damage PMID: 24219324
    35. IL-11 therefore drives a pathway that enhances HSPC radioresistance and radiation-induced B-cell malignancies, but is normally attenuated by the inhibitory adaptor Lnk. PMID: 24297922
    36. Solar simulted radiation-induced Il-11 may be involved in the photoaging-induced loss of facial subcutaneous fat. PMID: 23639700
    37. results suggest a two-step mechanism, whereby LfcinB induces TIMP-1 through an IL-11-dependent pathway involving transcription factor AP-1 and STAT3. PMID: 24036113
    38. induction of renal proximal tubule IL-11 is a critical intermediary in A1 adenosine receptor-mediated renal protection against acute ischemic kidney injury. PMID: 23813214
    39. the decreased ratio of IL-11/IL-17 might reflect an imbalance between the proinflammatory and anti-inflammatory cytokines in different periodontal diseases. PMID: 23226926
    40. An interleukin-6 family member, interleukin-11 is identified as a secondary target of twinfilin 1 in the microRNA-30c signalling pathway. PMID: 23340433
    41. Breast cancer cells may promote osteolysis in part by increasing the pool of osteoclast progenitor cells via tumor cell-derived IL-11. PMID: 23311882
    42. Enhanced production of IL-11 is associated with hepatocellular carcinoma metastasis to bone. PMID: 23307318
    43. IL11 is a hypoxia-inducible, VHL-regulated gene in human cancer cells and expression of IL11 mRNA is dependent, at least in part, on HIF-1. PMID: 23549086
    44. both the PI3K and Raf pathways are necessary for the expression of IL-11 in oncogenic Ras-mutated cells PMID: 23027619
    45. Data support the view that IL-11 is a key regulator of gastric damage acting to initiate chronic atrophic gastritis. PMID: 22180059
    46. IL-11 administration exhibits postconditioning effects through cardiac STAT3 activation, preventing myocardial ischemia-reperfusion injury. PMID: 22707562
    47. IL11 may be involved in endometrial cancer development PMID: 22614117
    48. Constructed a designer cytokine Hyper IL-11 (H11), which is exclusively composed of naturally existing components. It contains the full length sIL-11Ralpha connected with the mature IL-11 protein, and acts as an agonist on cells expressing the gp130 molec PMID: 22433466
    49. High Interleukin-11 is associated with multiple myeloma. PMID: 22289923
    50. Bovine lactoferrin administration prevented the progression of hepatic failure in human myofibroblasts and mice, and enhanced IL-11 and BMP2 expression in the small intestine. PMID: 21688123

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    IL-6 superfamily
  • 数据库链接：

    HGNC: 5966

    OMIM: 147681

    KEGG: hsa:3589

    STRING: 9606.ENSP00000264563

    UniGene: Hs.467304