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Human soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK)ELISA Kit

  • 中文名称:
    人可溶性肿瘤坏死因子样凋亡微弱诱导剂(sTWEAK)酶联免疫试剂盒
  • 货号:
    CSB-E16492h
  • 规格:
    96T/48T
  • 价格:
    ¥3600/¥2500
  • 其他:

产品详情

  • 产品描述:
        TNFSF12(肿瘤坏死因子超家族成员12)是一种细胞因子蛋白,其可以结合与其受体HVEM相互作用并促进T细胞和NK细胞的增殖和激活。TNFSF12在肿瘤治疗中具有很大的潜力,可以用于提高T细胞介导的免疫应答,抑制肿瘤生长和扩散。TNFSF12在人体中广泛表达,尤其在淋巴组织和免疫细胞中表达较高。
        j9九游会登录入口首页生物所提供的Human soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK)ELISA Kit属于ELISA检测试剂盒,采用双抗夹心法定量检测人血清、血浆、组织匀浆样本中的TNFSF12,其灵敏度为0.078 ng/ml,检测范围为0.312 ng/ml-20 ng/ml。
     
  • 别名:
    APO 3 ligand ELISA Kit; APO 3L ELISA Kit; APO3 ligand ELISA Kit; APO3/DR3 ligand ELISA Kit; APO3L ELISA Kit; DR3LG ELISA Kit; MGC129581 ELISA Kit; MGC20669 ELISA Kit; secreted form ELISA Kit; TNF-related weak inducer of apoptosis ELISA Kit; TNF12_HUMAN ELISA Kit; TNFSF 12 ELISA Kit; Tnfsf12 ELISA Kit; TNFSF12 protein ELISA Kit; Tumor necrosis factor (ligand) superfamily member 12 ELISA Kit; Tumor necrosis factor ligand superfamily member 12 ELISA Kit; Tumor necrosis factor superfamily member 12 ELISA Kit; TWEAK ELISA Kit; UNQ181/PRO207 ELISA Kit
  • 缩写:
    TNFSF12
  • Uniprot No.:
  • 种属:
    Homo sapiens (Human)
  • 样本类型:
    serum, plasma, tissue homogenates
  • 检测范围:
    0.312 ng/ml-20 ng/ml
  • 灵敏度:
    0.078 ng/ml
  • 反应时间:
    1-5h
  • 样本体积:
    50-100ul
  • 检测波长:
    450 nm
  • 研究领域:
    Cardiovascular
  • 测定原理:
    quantitative
  • 测定方法:
    Sandwich
  • 精密度:
     
  • 线性度:
     
  • 回收率:
     
  • 标准曲线:
     
  • 数据处理:
  • 货期:
    3-5 working days

产品评价

靶点详情

  • 最新研究进展:
    TNFSF12是一种细胞因子,也被称为TWEAK。最新的研究表明,它在肝癌等多种肿瘤的发生和进展中发挥着关键作用,并且可能成为治疗这些肿瘤的新靶点之一。
  • 功能:
    Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.
  • 基因功能参考文献:
    1. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
    2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
  • 亚细胞定位:
    Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor ligand superfamily member 12, secreted form]: Secreted.; [Isoform TWE-PRIL]: Cell membrane; Single-pass membrane protein.
  • 蛋白家族:
    Tumor necrosis factor family
  • 组织特异性:
    Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Als
  • 数据库链接:

    HGNC: 11927

    OMIM: 602695

    KEGG: hsa:407977

    UniGene: Hs.54673