thrB
THRB，即甲状腺激素受体β，别名C-ErbA-Beta2、NR1A2、THRbeta1等。它是一种核受体，由THRB基因编码，对三碘甲状腺原氨酸（T3）具有高亲和力。THRB的作用机制主要是通过与T3结合后，调控靶基因的转录，可以作为转录激活因子或抑制因子。THRB能够结合到基因组上的特定DNA序列上，调节多种生理过程，包括代谢、生长和发育。THRB在生物学上的意义非常广泛，它参与调节的信号通路涉及细胞的增殖、分化、能量代谢、神经系统发育等。THRB的功能异常与多种疾病有关，例如普遍性甲状腺激素抵抗症（Generalized Thyroid Hormone Resistance, GTHR），这是一种以甲状腺肿大和循环甲状腺激素（T3-T4）水平升高为特征的疾病，同时伴有正常或略高的甲状腺刺激激素（TSH）水平。此外，THRB的表达和活性还与肝脏的脂质代谢有关，研究发现，在THRB缺陷的小鼠中，肝脏的昼夜代谢节律发生显著变化，导致胆固醇、三酰甘油和二酰甘油以及脂肪酸水平升高，进而可能促进脂肪肝的发展。
热销产品
Recombinant Human Thyroid hormone receptor beta (THRB) (CSB-EP023514HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP023514HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) THRB.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP023514HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) THRB.
THRB Antibody (CSB-PA023514LA01HU)
验证数据
Western blot
All lanes: THRB antibody at 2µg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 53, 55 kDa
Observed band size: 53 kDa
Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA023514LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA023514LA01HU at dilution of 1:100
thrB Antibodies
thrB for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA050260 | Phospho-THRB (S142) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA050261 | THRB Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA023514LA01HU | THRB Antibody | Human, Mouse | ELISA, WB, IHC |
thrB Proteins
thrB Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023514HU CSB-BP023514HU CSB-MP023514HU CSB-EP023514HU-B |
Recombinant Human Thyroid hormone receptor beta (THRB) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP023514HU | Recombinant Human Thyroid hormone receptor beta (THRB) | E.coli |
