pdgfra
PDGFRA，即血小板衍生生长因子受体α，别名PDGFR-α、CD140A等。它是一种I型跨膜受体酪氨酸激酶，由人体细胞自身的基因编码。PDGFRA的作用机制主要是通过与其配体血小板衍生生长因子AA（PDGF-AA）、PDGF-AB、PDGF-CC等结合，引发受体二聚化和自身磷酸化，进而激活下游的信号传导途径。PDGFRA的激活可以促进多种细胞类型的增殖、迁移和存活，包括成纤维细胞、周细胞和血管平滑肌细胞等。PDGFRA在生物学上的意义非常广泛，它在胚胎发育、组织修复、肿瘤发生发展等过程中发挥关键作用。PDGFRA信号的异常激活与多种肿瘤的发生发展密切相关，如胃肠道间质瘤、神经胶质瘤等。此外，PDGFRA还参与调控肿瘤微环境中的血管生成和免疫细胞的浸润，影响肿瘤的免疫逃逸和药物耐受。因此，PDGFRA是肿瘤治疗中的一个重要靶点，针对PDGFRA的小分子抑制剂和单克隆抗体等药物已在临床治疗中得到应用。
热销产品
PDGFRA Antibody (CSB-PA017712LA01HU)
验证数据
Western Blot
Positive WB detected in: HEK293 whole cell lysate, Mouse liver tissue
All lanes: PDGFRA antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 123, 25, 83 kDa
Observed band size: 123 kDa
Immunofluorescent analysis of U251 cells using CSB-PA017712LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
pdgfra Antibodies
pdgfra for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA123585 | Phospho-PDGFRA (Tyr849) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA003724 | PDGFRA Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA005257 | PDGFRA Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA020304 | Phospho-PDGFRA (Y849) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA020305 | Phospho-PDGFRA (Y762) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA020306 | Phospho-PDGFRA (Y754) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA020307 | PDGFRA Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA020308 | PDGFRA Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA030000 | PDGFRA Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA030001 | PDGFRA Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA017712LA01HU | PDGFRA Antibody | Human, Mouse | ELISA, WB, IF |
| CSB-PA017712LB01HU | PDGFRA Antibody, HRP conjugated | Human | ELISA |
| CSB-PA017712LC01HU | PDGFRA Antibody, FITC conjugated | Human | |
| CSB-PA017712LD01HU | PDGFRA Antibody, Biotin conjugated | Human | ELISA |
pdgfra Proteins
pdgfra Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP017712HU CSB-EP017712HU CSB-BP017712HU CSB-MP017712HU CSB-EP017712HU-B |
Recombinant Human Platelet-derived growth factor receptor alpha (PDGFRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
pdgfra Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP017712RA CSB-EP017712RA CSB-BP017712RA CSB-MP017712RA CSB-EP017712RA-B |
Recombinant Rat Platelet-derived growth factor receptor alpha (Pdgfra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
pdgfra Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP017712MO CSB-EP017712MO CSB-BP017712MO CSB-MP017712MO CSB-EP017712MO-B |
Recombinant Mouse Platelet-derived growth factor receptor alpha (Pdgfra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
pdgfra Proteins for Xenopus laevis (African clawed frog)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP326307XBE CSB-EP326307XBE CSB-BP326307XBE CSB-MP326307XBE CSB-EP326307XBE-B |
Recombinant Xenopus laevis Platelet-derived growth factor receptor alpha (pdgfra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
pdgfra Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP804293TKY CSB-EP804293TKY CSB-BP804293TKY CSB-MP804293TKY CSB-EP804293TKY-B |
Recombinant Takifugu rubripes Platelet-derived growth factor receptor alpha (pdgfra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
pdgfra Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP866765DIL CSB-EP866765DIL CSB-BP866765DIL CSB-MP866765DIL CSB-EP866765DIL-B |
Recombinant Danio rerio Platelet-derived growth factor receptor alpha (pdgfra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
pdgfra Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP889488CH CSB-EP889488CH CSB-BP889488CH CSB-MP889488CH CSB-EP889488CH-B |
Recombinant Chicken Platelet-derived growth factor receptor alpha (PDGFRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP017708CH CSB-EP017708CH-B |
Recombinant Chicken Platelet-derived growth factor receptor alpha (PDGFRA) | E.coli In Vivo Biotinylation in E.coli |
pdgfra ELISA Kit
pdgfra ELISA Kit for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E04699m | Mouse Platelet-Derived Growth Factor Soluble Receptor α,PDGFsR-α ELISA kit | serum, plasma, tissue homogenates, cell lysates | 3.9 pg/mL |
