Smo
SMO，即平滑蛋白，别名Smoothened。它是一种细胞表面受体，属于F类G蛋白偶联受体（GPCR）家族成员，是Hedgehog（Hh）信号通路中的关键组分。SMO在细胞内主要通过与Hh配体结合，被激活后能够将信号传导至细胞核，进而激活GLI转录因子，调控相关基因的表达。SMO的来源是人体细胞自身的基因编码，其作用机制涉及到与多种蛋白质和脂质分子的相互作用，尤其是胆固醇的共价修饰对SMO的功能至关重要 。SMO在生物学上的意义非常重大，它不仅参与调控胚胎发育、组织再生和器官修复等生理过程，而且与多种癌症的发生发展密切相关。Hh信号通路在静息状态下，SMO受到Patched（PTCH）蛋白的抑制；当Hh配体结合PTCH时，SMO受到的抑制被解除，从而激活下游信号通路。此外，SMO的异常激活与胶质瘤等多种肿瘤的发生密切相关，因此，SMO成为了抗癌药物开发的重要靶点 。
热销产品
验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA155823(SMO Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA155823(SMO Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
Smo Antibodies
Smo for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA050108 | SMO Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA155823 | SMO Antibody | Human,Rat | ELISA,IHC |
| CSB-PA857876LA01HU | SMO Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA857876LB01HU | SMO Antibody, HRP conjugated | Human | ELISA |
| CSB-PA857876LC01HU | SMO Antibody, FITC conjugated | Human | |
| CSB-PA857876LD01HU | SMO Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA288930GA01HU | SMO Antibody | Human, Mouse, Rat | ELISA, WB |
Smo Proteins
Smo Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP021841RA1 CSB-EP021841RA1 CSB-BP021841RA1 CSB-MP021841RA1 CSB-EP021841RA1-B |
Recombinant Rat Smoothened homolog (Smo), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF021841RA | Recombinant Rat Smoothened homolog (Smo) | in vitro E.coli expression system |
Smo Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP021841MO1 CSB-EP021841MO1 CSB-BP021841MO1 CSB-MP021841MO1 CSB-EP021841MO1-B |
Recombinant Mouse Smoothened homolog (Smo), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF021841MO | Recombinant Mouse Smoothened homolog (Smo) | in vitro E.coli expression system |
Smo Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP021841CH1 CSB-EP021841CH1 CSB-BP021841CH1 CSB-MP021841CH1 CSB-EP021841CH1-B |
Recombinant Chicken Smoothened homolog (SMO), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF021841CH | Recombinant Chicken Smoothened homolog (SMO) | in vitro E.coli expression system |
Smo Proteins for Drosophila melanogaster (Fruit fly)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP309724DLU CSB-EP309724DLU CSB-BP309724DLU CSB-MP309724DLU CSB-EP309724DLU-B |
Recombinant Drosophila melanogaster Protein smoothened (smo), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Smo Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP857876HU1 CSB-EP857876HU1 CSB-BP857876HU1 CSB-MP857876HU1 CSB-EP857876HU1-B |
Recombinant Human Smoothened homolog (SMO), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF857876HU | Recombinant Human Smoothened homolog (SMO) | in vitro E.coli expression system |
