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Pdgfra

PDGFRA,即血小板衍生生长因子受体α,别名PDGFR-α、CD140A等。它是一种I型跨膜受体酪氨酸激酶,由人体细胞自身的基因编码。PDGFRA的作用机制主要是通过与其配体血小板衍生生长因子AA(PDGF-AA)、PDGF-AB、PDGF-CC等结合,引发受体二聚化和自身磷酸化,进而激活下游的信号传导途径。PDGFRA的激活可以促进多种细胞类型的增殖、迁移和存活,包括成纤维细胞、周细胞和血管平滑肌细胞等。PDGFRA在生物学上的意义非常广泛,它在胚胎发育、组织修复、肿瘤发生发展等过程中发挥关键作用。PDGFRA信号的异常激活与多种肿瘤的发生发展密切相关,如胃肠道间质瘤、神经胶质瘤等。此外,PDGFRA还参与调控肿瘤微环境中的血管生成和免疫细胞的浸润,影响肿瘤的免疫逃逸和药物耐受。因此,PDGFRA是肿瘤治疗中的一个重要靶点,针对PDGFRA的小分子抑制剂和单克隆抗体等药物已在临床治疗中得到应用。

热销产品

PDGFRA Antibody (CSB-PA017712LA01HU)

验证数据

CSB-PA017712LA01HU

Western Blot
Positive WB detected in: HEK293 whole cell lysate, Mouse liver tissue
All lanes: PDGFRA antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 123, 25, 83 kDa
Observed band size: 123 kDa

CSB-PA017712LA01HU

Immunofluorescent analysis of U251 cells using CSB-PA017712LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Pdgfra Antibodies

Pdgfra for Homo sapiens (Human)

Pdgfra Proteins

Pdgfra Proteins for Homo sapiens (Human)

Pdgfra Proteins for Rattus norvegicus (Rat)

Pdgfra Proteins for Mus musculus (Mouse)

Pdgfra Proteins for Xenopus laevis (African clawed frog)

Pdgfra Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

Pdgfra Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

Pdgfra Proteins for Gallus gallus (Chicken)

Pdgfra ELISA Kit

Pdgfra ELISA Kit for Mus musculus (Mouse)