Pde5a
PDE5A，即磷酸二酯酶5A，别名cGMP-binding cGMP-specific phosphodiesterase、CGB-PDE。它是磷酸二酯酶家族中的一员，主要在心血管系统和中枢神经系统中发挥作用。它通过水解cGMP（环磷酸鸟苷）和cAMP（环磷酸腺苷），调节细胞内信号传导，影响血管舒张、血小板功能和神经传递。PDE5A的活性与多种疾病相关，包括心血管疾病、性功能障碍和某些类型的癌症。PDE5A抑制剂，如西地那非，被用于治疗勃起功能障碍和肺动脉高压，同时，它们还可能在神经保护和抗癌领域发挥作用。因此，PDE5A是药物开发和疾病治疗中的一个关键靶点。
热销产品
Recombinant Human cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A) , partial (CSB-YP524921HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA126186(PDE5A Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA126186(PDE5A Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: CSB-PA126186(PDE5A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
Pde5a Antibodies
Pde5a for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA126186 | PDE5A Antibody | Human | ELISA,WB,IHC |
| CSB-PA132496 | PDE5A Antibody | Human | ELISA,IHC |
Pde5a Proteins
Pde5a Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP523851RA CSB-EP523851RA CSB-BP523851RA CSB-MP523851RA CSB-EP523851RA-B |
Recombinant Rat cGMP-specific 3',5'-cyclic phosphodiesterase (Pde5a), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Pde5a Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-EP524921HU CSB-BP524921HU CSB-MP524921HU CSB-EP524921HU-B |
Recombinant Human cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP524921HU | Recombinant Human cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A) , partial | Yeast |
Pde5a Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP529249DO CSB-EP529249DO CSB-BP529249DO CSB-MP529249DO CSB-EP529249DO-B |
Recombinant Dog cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Pde5a Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP634661BO CSB-EP634661BO CSB-BP634661BO CSB-MP634661BO CSB-EP634661BO-B |
Recombinant Bovine cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Pde5a Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP807017MO CSB-BP807017MO CSB-MP807017MO CSB-EP807017MO-B |
Recombinant Mouse cGMP-specific 3',5'-cyclic phosphodiesterase (Pde5a), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP807017MO | Recombinant Mouse cGMP-specific 3,5-cyclic phosphodiesterase (Pde5a), partial | E.coli |
